{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,22]],"date-time":"2025-03-22T11:01:33Z","timestamp":1742641293975},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,10,29]],"date-time":"2019-10-29T00:00:00Z","timestamp":1572307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81772755"],"award-info":[{"award-number":["81772755"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the predictive value of common preoperative laboratory variables in patients undergoing bilateral inguinal lymph node dissection surgery for penile squamous cell carcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analyzed the records of 228 patients who had bilateral inguinal lymph node dissection for penile squamous cell carcinoma to assess the following clinical factors: preoperative laboratory measurements, white blood cell count, platelet count, neutrophil\u2010to\u2010lymphocyte ratio, platelet\u2010to\u2010lymphocyte ratio, serum calcium, total protein, globulin, pathological factors and survival rates after surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The percentage of positive lymph nodes was 52.6%. Univariate analysis showed that the tumor stage and grade, the presence of metastasis, white blood cell\u00a0count, platelet count, neutrophil\u2010to\u2010lymphocyte ratio, platelet\u2010to\u2010lymphocyte ratio, and globulin were significantly associated with the disease\u2010specific survival (all <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). At multivariate analysis, only the neutrophil\u2010to\u2010lymphocyte ratio had an independent effect (hazard ratio 2.131; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.035). The predictive accuracy of the neutrophil\u2010to\u2010lymphocyte ratio was the best among the laboratory variables. The predictive accuracy of the basic pathological factors was significantly increased by incorporating the neutrophil\u2010to\u2010lymphocyte ratio prognosticator.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The neutrophil\u2010to\u2010lymphocyte ratio before inguinal lymph node dissection might be useful for predicting the prognosis of patients with penile squamous cell carcinoma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.14137","type":"journal-article","created":{"date-parts":[[2019,10,30]],"date-time":"2019-10-30T00:19:51Z","timestamp":1572394791000},"page":"76-82","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Prognostic significance of common preoperative laboratory variables in penile squamous cell carcinoma"],"prefix":"10.1111","volume":"27","author":[{"given":"Zaishang","family":"Li","sequence":"first","affiliation":[{"name":"Department of Urology Shenzhen People\u2019s Hospital The First Affiliated Hospital of Southern University of Science and Technology Shenzhen China"},{"name":"Department of Urology The Second Clinical College of Jinan University Shenzhen China"},{"name":"Department of Urology Sun Yat\u2010sen University Cancer Center Guangzhou China"},{"name":"State Key Laboratory of Oncology in Southern China Guangzhou China"},{"name":"Collaborative Innovation Center of Cancer Medicine Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueying","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology The Seventh Hospital of Sun Yat\u2010sen University Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueqi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Urology Shenzhen People\u2019s Hospital The First Affiliated Hospital of Southern University of Science and Technology Shenzhen China"},{"name":"Department of Urology The Second Clinical College of Jinan University Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Urology Affiliated Tumor Hospital of Xinjiang Medical University Urumchi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Urology Cancer Center of Guangzhou Medical University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofeng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Urology The First People's Hospital of Chenzhou Chenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Urology Sun Yat\u2010sen University Cancer Center Guangzhou China"},{"name":"State Key Laboratory of Oncology in Southern China Guangzhou China"},{"name":"Collaborative Innovation Center of Cancer Medicine Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fangjian","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Urology Sun Yat\u2010sen University Cancer Center Guangzhou China"},{"name":"State Key Laboratory of Oncology in Southern China Guangzhou China"},{"name":"Collaborative Innovation Center of Cancer Medicine Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,10,29]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines): Penile Cancer","author":"Flaig TW","year":"2019"},{"key":"e_1_2_8_3_1","unstructured":"HakenbergOW Comp\u00e9ratE MinhasS NecchiA ProtzelC WatkinN.EAU guidelines on penile cancer.2019. 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