{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T09:15:36Z","timestamp":1785402936285,"version":"3.56.0"},"reference-count":7,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,10,29]],"date-time":"2019-10-29T00:00:00Z","timestamp":1572307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the initial response to intravesical bacillus Calmette\u2013Gu\u00e9rin and the 3\u2010year recurrence rate of high\u2010risk non\u2010muscle\u2010invasive bladder cancer in patients who have asymptomatic bacteriuria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Response and recurrence rates were investigated in 505 patients with high\u2010risk non\u2010muscle\u2010invasive bladder cancer after treatment with induction bacillus Calmette\u2013Gu\u00e9rin (TICE strain) therapy. Initial response was determined after 3\u00a0months and patients were followed every 3\u20136\u00a0months for 3\u00a0years. Before bacillus Calmette\u2013Gu\u00e9rin and each follow\u2010up cystoscopy, urine cultures were obtained, stratified as no growth, &lt;104, &gt;104 or\u00a0&gt;105\u00a0colony\u2010forming unit\/mL. Any degree of bacteriuria on culture was classified as asymptomatic bacteriuria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 505 cases, 270 (53%) had asymptomatic bacteriuria. A total of 89% of patients with asymptomatic bacteriuria showed a complete response to bacillus Calmette\u2013Gu\u00e9rin versus 76% of uninfected patients (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.001), and 75% of bacteriuric patients survived tumor\u2010free for 3\u00a0years versus 65% of uninfected patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Chronic bacteriuria might enhance the response of high\u2010risk non\u2010muscle\u2010invasive bladder cancer to intravesical bacillus Calmette\u2013Gu\u00e9rin and result in longer tumor\u2010free survival than uninfected patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.14139","type":"journal-article","created":{"date-parts":[[2019,10,29]],"date-time":"2019-10-29T23:53:42Z","timestamp":1572393222000},"page":"72-74","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Does asymptomatic bacteriuria affect the response to intravesical bacillus Calmette\u2013Gu\u00e9rin?"],"prefix":"10.1111","volume":"27","author":[{"given":"Harry","family":"Herr","sequence":"first","affiliation":[{"name":"Urology Service Department of Surgery Memorial Sloan Kettering Cancer Center New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2011.03.051"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.428"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2013.72"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0028289"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2011.10.032"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2014.361"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2007050611"}],"container-title":["International Journal of Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fiju.14139","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iju.14139","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/iju.14139","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iju.14139","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T21:30:26Z","timestamp":1694122226000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iju.14139"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,29]]},"references-count":7,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1111\/iju.14139"],"URL":"https:\/\/doi.org\/10.1111\/iju.14139","archive":["Portico"],"relation":{},"ISSN":["0919-8172","1442-2042"],"issn-type":[{"value":"0919-8172","type":"print"},{"value":"1442-2042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,29]]},"assertion":[{"value":"2019-07-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}