{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T16:59:21Z","timestamp":1783875561357,"version":"3.55.0"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T00:00:00Z","timestamp":1575244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To identify the clinicopathological features of malignant urachal tumor in Japan, and analyze the 5\u2010year overall survival of malignant urachal tumor patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used the hospital\u2010based cancer registry data to extract malignant urachal tumor cases that were diagnosed in 2008\u20132009 and 2012\u20132015, histologically confirmed, and received the first course of treatment. We analyzed the 5\u2010year overall survival using the 2008\u20132009 cohort\u2019s data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 456 patients, and malignant urachal tumor accounted for 0.4% of all malignant bladder cancers. The median age was 61\u00a0years (range 2\u201397), and 66% were men. The most common histology was adenocarcinoma (80%), followed by urothelial carcinoma (11%) and squamous cell carcinoma (3%). The proportions of patients were: 19% Ta\/Tis\/T1N0M0, 55% T2\u20133N0M0, 13% T4\/N+ and 13% M+. Regarding the initial treatment, the proportions of surgery alone were 79% and 33% in cases of T3 or less N0M0 and T4\/N+, respectively. The proportion of combination therapy including surgery and chemotherapy were 13% and 44% in T2\u20133N0M0 and T4\/N+, respectively. Radiation therapy was not common at any stage. In the 2008\u20132009 cohort, the 5\u2010year overall survival rate in Ta\/Tis\/T1N0M0, T2\u20133N0M0, T4\/N+ and M+ were 60%, 64%, 63% and 12%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Malignant urachal tumors are quite rare in Japan, and most of those without metastasis are likely to be treated by surgery alone, even at advanced stages. A standard of care must be established for malignant urachal tumor patients at advanced stages or with metastasis, as the prognosis of these patients can be poor.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.14154","type":"journal-article","created":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T08:26:24Z","timestamp":1575361584000},"page":"157-162","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Clinicopathological features of malignant urachal tumor: A hospital\u2010based cancer registry data in Japan"],"prefix":"10.1111","volume":"27","author":[{"given":"Yoshiyuki","family":"Nagumo","sequence":"first","affiliation":[{"name":"Department of Urology University of Tsukuba Tsukuba Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Kojima","sequence":"additional","affiliation":[{"name":"Department of Urology University of Tsukuba Tsukuba Ibaraki 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