{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:52:21Z","timestamp":1787014341583,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,1,16]],"date-time":"2020-01-16T00:00:00Z","timestamp":1579132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate the effects of an alpha1\u2010adrenoceptor antagonist, silodosin, or a phosphodiesterase type\u00a05 inhibitor, tadalafil, on bladder overactivity in spontaneously hypertensive rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twelve\u2010week\u2010old male spontaneously hypertensive rats were perorally administered silodosin (100\u00a0\u00b5g\/kg), tadalafil (2 or 10\u00a0mg\/kg) or vehicle once daily for 6\u00a0weeks. Wistar rats were used as normotensive controls and were treated with the vehicle. At 18\u2010weeks\u2010old, the effects of silodosin or tadalafil on blood pressure, bladder blood flow, urodynamic parameters (i.e. micturition frequency, urine output, inter\u2010contraction interval, maximum voiding pressure, single voided volume and post\u2010voiding residual urine volume), and bladder tissue levels of malondialdehyde, interleukin\u20106 and tumor necrosis factor\u2010alpha were measured.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A significant increase in blood pressure, micturition frequency and bladder tissue levels of malondialdehyde, interleukin\u20106 and tumor necrosis factor\u2010alpha was noted in spontaneously hypertensive rats. The single voided volume, bladder capacity and bladder blood flow were significantly lower in the spontaneously hypertensive rats than in the Wistar rats. Treatment with silodosin and the higher dose of tadalafil improved the urodynamic parameters, bladder blood flow and bladder tissue levels of malondialdehyde in the spontaneously hypertensive rats without affecting the blood pressure and bladder tissue levels of interleukin\u20106 and tumor necrosis factor\u2010alpha.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Treatment with silodosin or tadalafil might improve hypertension\u2010related bladder overactivity, as shown in spontaneously hypertensive rats through an improvement in the bladder blood flow and bladder tissue levels of oxidative stress.<\/jats:p>\n                  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