{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T08:23:11Z","timestamp":1787818991765,"version":"build-2784847793"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,2,25]],"date-time":"2020-02-25T00:00:00Z","timestamp":1582588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To carry out a comparison of upper urinary tract urothelial carcinoma characteristics and behavior between patients in Taiwan and Japan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A Taiwan urinary tract urothelial carcinoma cohort was obtained from Kaohsiung Chang Gung Memorial Hospital, and a Japan urinary tract urothelial carcinoma cohort from Hirosaki University Hospital. The inclusion criteria were urinary tract urothelial carcinoma patients who underwent radical nephroureterectomy. Those who received perioperative chemotherapy were excluded. Finally, 765 patients in the Taiwan cohort and 325 in the Japan cohort were analyzed. The end\u2010point of this study was to study the natural course of urinary tract urothelial carcinoma within 5\u00a0years between these two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The main finding was that urinary tract urothelial carcinoma patients in Taiwan were younger (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), more were women (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), with low\u2010stage disease (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), with more chronic kidney disease (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), with less smoking history (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), with more bladder cancer history (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.002), with more multifocal (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and less high\u2010grade disease (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.015), as well as less lymphovascular invasion (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and more squamous differentiation (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). However, the multivariate Cox regression analysis showed no racial difference in oncologic outcome, such as intravesical recurrence, systemic recurrence or cancer\u2010specific death in primary and propensity\u2010matched cohorts. Bladder cancer history was found to be the most important factor predicting intravesical recurrences, whereas stage was strongly associated with systemic recurrence and cancer specific mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The clinical characteristics of urinary tract urothelial carcinoma in Taiwan are significantly different from those of urinary tract urothelial carcinoma in Japan. However, there is no racial difference in stage\u2010specific oncologic outcome after standard nephroureterectomy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.14188","type":"journal-article","created":{"date-parts":[[2020,2,26]],"date-time":"2020-02-26T07:02:59Z","timestamp":1582700579000},"page":"327-332","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Unusual presentation of upper urinary tract urothelial carcinoma in Taiwan: Direct comparison from Taiwan\u2010Japan UTUC Collaboration Cohort"],"prefix":"10.1111","volume":"27","author":[{"given":"Hao Lun","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Urology Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chikara","family":"Ohyama","sequence":"additional","affiliation":[{"name":"Department of Advanced Transplant and Regenerative Medicine Hirosaki University Graduate School of Medicine Hirosaki Aomori Japan"},{"name":"Department of Urology Hirosaki University Graduate School of Medicine Hirosaki Aomori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shingo","family":"Hatakeyama","sequence":"additional","affiliation":[{"name":"Department of Urology Hirosaki University Graduate School of Medicine Hirosaki Aomori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hung Jen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Urology Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tohru","family":"Yoneyama","sequence":"additional","affiliation":[{"name":"Department of Advanced Transplant and Regenerative Medicine Hirosaki University Graduate School of Medicine Hirosaki Aomori Japan"},{"name":"Department of Urology Hirosaki University Graduate School of Medicine Hirosaki Aomori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen Chou","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Urology Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao Chi","family":"Chuang","sequence":"additional","affiliation":[{"name":"Department of Urology Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen Ta","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Urology Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei Chin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Urology Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan Tso","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Urology Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih Hsiung","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Urology Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po Hui","family":"Chiang","sequence":"additional","affiliation":[{"name":"Department of Urology Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.12582"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2013.04.001"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.24815"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euf.2018.03.003"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2017.417"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.14020"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2016.06.013"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2008.07565.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28013"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1613683"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19990315)85:6<1342::AID-CNCR17>3.0.CO;2-B"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24135"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000003255"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2010.06.029"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2042.2011.02913.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S148641"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40264-014-0244-x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3006086"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.12707"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.69.4141"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.21551"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-016-1995-z"}],"container-title":["International Journal of Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fiju.14188","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iju.14188","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/iju.14188","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iju.14188","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T02:21:07Z","timestamp":1694053267000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iju.14188"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,25]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["10.1111\/iju.14188"],"URL":"https:\/\/doi.org\/10.1111\/iju.14188","archive":["Portico"],"relation":{},"ISSN":["0919-8172","1442-2042"],"issn-type":[{"value":"0919-8172","type":"print"},{"value":"1442-2042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,25]]},"assertion":[{"value":"2019-10-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}