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Peyronie\u2019s disease represents a penile wound healing disorder, and is thought to arise from exuberant scarring in response to penile trauma in genetically predisposed men. In the absence of active treatment, the majority of men experience stable or worsening symptoms, with few reporting spontaneous resolution in penile curvature or other deformity. In contrast, penile pain improves or resolves in the majority of men. Treatment options vary based on symptom severity and stability. Several oral therapies are commonly prescribed, although to date there are no strong data to support any oral agents as monotherapy for Peyronie\u2019s disease. Other options including penile traction therapy and intralesional injections result in modest improvements for many patients, particularly when used early after symptom onset. Penile straightening through approaches, such as penile plication and plaque incision or partial excision and grafting, represent the most rapid and reliable approach to correct penile curvature once the symptoms have stabilized. Side\u2010effects vary based on the type of surgery carried out, and include penile shortening, sensation changes and erectile dysfunction in the minority of men. In patients with drug refractory erectile dysfunction and Peyronie\u2019s disease, placement of a penile prosthesis will address both issues, and is associated with high levels of patient satisfaction. The current review provides a practical approach to the modern evaluation and management of patients presenting with Peyronie\u2019s disease.<\/jats:p>","DOI":"10.1111\/iju.14230","type":"journal-article","created":{"date-parts":[[2020,4,6]],"date-time":"2020-04-06T20:19:57Z","timestamp":1586204397000},"page":"504-516","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":72,"title":["Peyronie\u2019s disease: Contemporary evaluation and management"],"prefix":"10.1111","volume":"27","author":[{"given":"Matthew J","family":"Ziegelmann","sequence":"first","affiliation":[{"name":"Division of Urology Rush University Medical Center Chicago Illinois USA"},{"name":"Department of Urology Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petar","family":"Bajic","sequence":"additional","affiliation":[{"name":"Division of Urology Rush University Medical Center Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence A","family":"Levine","sequence":"additional","affiliation":[{"name":"Division of Urology Rush University Medical Center Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,6]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"425","article-title":"Sur quelques obstacles qui s' opposent a l'ejaculation naturelle de la semence","volume":"1","author":"Peyronie F","year":"1743","journal-title":"Mem. 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