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The current guidelines define interstitial cystitis\/bladder pain syndrome as a condition with chronic pelvic pain, pressure or discomfort perceived to be related to the urinary bladder accompanied by other urinary symptoms, such as persistent urge to void or urinary frequency in the absence of confusable diseases. The characteristic symptom complex is collectively referred as hypersensitive bladder symptoms. Interstitial cystitis\/bladder pain syndrome is divided into Hunner\u2010type interstitial cystitis and bladder pain syndrome; Hunner\u2010type interstitial cystitis and bladder pain syndrome represent interstitial cystitis\/bladder pain syndrome with Hunner lesions and interstitial cystitis\/bladder pain syndrome without Hunner lesions, respectively. So\u2010called non\u2010Hunner\u2010type interstitial cystitis featured by glomerulations or bladder bleeding after distension is included in bladder pain syndrome. The symptoms are virtually indistinguishable between Hunner\u2010type interstitial cystitis and bladder pain syndrome; however, Hunner\u2010type interstitial cystitis and bladder pain syndrome should be considered as a separate entity of disorder. Histopathology totally differs between Hunner\u2010type interstitial cystitis and bladder pain syndrome; Hunner\u2010type interstitial cystitis is associated with severe inflammation of the urinary bladder accompanied by lymphoplasmacytic infiltration and urothelial denudation, whereas bladder pain syndrome shows little pathological changes in the bladder. Pathophysiology would also differ between Hunner\u2010type interstitial cystitis and bladder pain syndrome, involving interaction of multiple factors, such as inflammation, autoimmunity, infection, exogenous substances, urothelial dysfunction, neural hyperactivity and extrabladder disorders. The patients should be treated differently based on the diagnosis of Hunner\u2010type interstitial cystitis or bladder pain syndrome, which requires cystoscopy to determine the presence or absence Hunner lesions. Clinical studies are to be designed to analyze outcomes separately for Hunner\u2010type interstitial cystitis and bladder pain syndrome.<\/jats:p>","DOI":"10.1111\/iju.14234","type":"journal-article","created":{"date-parts":[[2020,4,14]],"date-time":"2020-04-14T20:30:50Z","timestamp":1586896250000},"page":"578-589","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":225,"title":["Clinical guidelines for interstitial cystitis\/bladder pain syndrome"],"prefix":"10.1111","volume":"27","author":[{"given":"Yukio","family":"Homma","sequence":"first","affiliation":[{"name":"Department of Urology Japanese Red Cross Medical Center Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyuki","family":"Akiyama","sequence":"additional","affiliation":[{"name":"Department of Urology Graduate School of Medicine The University of Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hikaru","family":"Tomoe","sequence":"additional","affiliation":[{"name":"Department of Urology Tokyo Women\u2019s Medical University Medical Center East Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Furuta","sequence":"additional","affiliation":[{"name":"Department of Urology Jikei University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Ueda","sequence":"additional","affiliation":[{"name":"Department of Urology Ueda Clinic Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daichi","family":"Maeda","sequence":"additional","affiliation":[{"name":"Department of Clinical Genomics Graduate School of Medicine Osaka University Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex TL","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Urology Taipei Veterans General Hospital National Yang Ming University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hann\u2010Chorng","family":"Kuo","sequence":"additional","affiliation":[{"name":"Department of Urology School of Medicine Buddhist Tzu Chi General Hospital Tzu Chi University Hualien Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Huei","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Urology Feng\u2010Yuan Hospital Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung\u2010June","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Urology Seoul National University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joon Chul","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Urology The Catholic University of Korea Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyu\u2010Sung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Urology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,14]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2042.2009.02326.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.13118"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.13970"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2007.09.019"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2011.03.064"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2015.01.086"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.12314"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000000234"},{"key":"e_1_2_5_10_1","first-page":"25","article-title":"Pathology and terminology of interstitial cystitis\/bladder pain syndrome: a review","volume":"34","author":"Akiyama Y","year":"2019","journal-title":"Histol. 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