{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T16:42:57Z","timestamp":1791650577801,"version":"4.3.4"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,4,19]],"date-time":"2020-04-19T00:00:00Z","timestamp":1587254400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["H29\u2010Ganseisaku\u2010Ippan\u2010026"],"award-info":[{"award-number":["H29\u2010Ganseisaku\u2010Ippan\u2010026"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the clinical characteristics of patients with penile cancer in Japan using the nationwide hospital\u2010based cancer registry database.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using hospital\u2010based cancer registry data, we described the distribution of age, pathology, tumor\u2013node\u2013metastases classification, and first\u2010course treatment in patients treated between 2012 and 2015. We compared the patterns of first\u2010line treatment between elderly and non\u2010elderly patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1012 patients were diagnosed with squamous cell carcinoma among 1773 patients with penile tumors who registered under topography code C60. The median age at diagnosis was 74\u00a0years, and 85.9% of patients were aged &gt;60\u00a0years. The most common pathology was usual\u2010type squamous cell carcinoma (91.9%), followed by verrucous carcinoma (5.0%), sarcomatoid carcinoma (1.1%), papillary carcinoma (0.7%), basaloid carcinoma (0.6%), adenosquamous carcinoma (0.4%), warty carcinoma (0.2%) and mixed carcinoma (0.1%). A total of 61.3% of patients were diagnosed with localized disease. In contrast, the proportions of patients with lymph node and distant metastases were 27.5% and 2.1% at diagnosis, respectively. The proportion of patients who were treated with chemotherapy as the first\u2010course treatment was significantly lower among elderly patients (\u226580\u00a0years) with clinical stage\u00a0III (27.6% <jats:italic>vs<\/jats:italic> 7.1%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0312) and clinical stage\u00a0IV (53.2% <jats:italic>vs<\/jats:italic> 14.3%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0086).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Most penile cancer patients in Japan are diagnosed with usual\u2010type squamous cell carcinoma, and those with human papilloma virus\u2010related squamous cell carcinomas are &lt;1%. Chemotherapy for advanced penile cancer is administered less in Japanese elderly (\u226580\u00a0years) patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.14247","type":"journal-article","created":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T02:34:59Z","timestamp":1587350099000},"page":"538-542","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Characteristics of penile cancer in Japan: An analysis of nationwide hospital\u2010based cancer registry data"],"prefix":"10.1111","volume":"27","author":[{"given":"Ken","family":"Tanaka","sequence":"first","affiliation":[{"name":"Department of Urology Faculty of Medicine University of Tsukuba Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuya","family":"Kandori","sequence":"additional","affiliation":[{"name":"Department of Urology Faculty of Medicine University of Tsukuba Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Nitta","sequence":"additional","affiliation":[{"name":"Department of Urology Faculty of Medicine University of Tsukuba Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiro","family":"Chihara","sequence":"additional","affiliation":[{"name":"Department of Urology Faculty of Medicine University of Tsukuba Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kosuke","family":"Kojo","sequence":"additional","affiliation":[{"name":"Department of Urology Faculty of Medicine University of Tsukuba Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyuki","family":"Nagumo","sequence":"additional","affiliation":[{"name":"Department of Urology Faculty of Medicine University of Tsukuba Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomokazu","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Urology Faculty of Medicine University of Tsukuba Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Kojima","sequence":"additional","affiliation":[{"name":"Department of Urology Faculty of Medicine University of Tsukuba Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Kawai","sequence":"additional","affiliation":[{"name":"Department of Urology Faculty of Medicine University of Tsukuba Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayako","family":"Okuyama","sequence":"additional","affiliation":[{"name":"Centre for Cancer Registries Center for Cancer Control and Information Services National Cancer Center Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Higashi","sequence":"additional","affiliation":[{"name":"Centre for Cancer Registries Center for Cancer Control and Information Services National Cancer Center Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Nishiyama","sequence":"additional","affiliation":[{"name":"Department of Urology Faculty of Medicine University of Tsukuba Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23743"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2006.08.029"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25355"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-011-9876-7"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.31194"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-013-0293-y"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2018.12.003"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2010.03.003"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)62506-0"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/106689690401200408"},{"key":"e_1_2_8_12_1","first-page":"2513","article-title":"The role of human papilloma virus in urological malignancies","volume":"35","author":"Heidegger I","year":"2015","journal-title":"Anticancer Res."},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30682-X"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2042.1998.tb00598.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hym020"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyt013"},{"key":"e_1_2_8_17_1","volume-title":"International Classification of Diseases for Oncology","author":"Jack A","year":"2000"},{"key":"e_1_2_8_18_1","volume-title":"Union for International Cancer Control. 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