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Androgen deprivation therapy is the primary treatment for patients with advanced prostate cancer at disease presentation, which can be achieved either with surgical or chemical castration. The development of gonadotropin\u2010releasing hormone agonists revolutionized the treatment of advanced prostate cancer, replacing the need for surgical castration. Agonists downregulate gonadotropin\u2010releasing hormone agonist receptors in the pituitary gland, and thus decrease the release of luteinizing hormone and testosterone. Although agonists are a common therapeutic option to date, their use is associated with testosterone surges, metabolic dysfunction and an increase in the risk of cardiovascular disease; they might contribute to tumor flares and potentially an increase in non\u2010cancer mortality. More recently, gonadotropin\u2010releasing hormone antagonists have entered the prostate cancer treatment landscape. Unlike agonists, antagonists directly inhibit the androgen receptor in the pituitary gland, and thus do not cause initial testosterone surges. In this article, we provide a concise review of the mechanism of actions, safety and efficacy of the approved agonists and antagonists for prostate cancer treatment.<\/jats:p>","DOI":"10.1111\/iju.14303","type":"journal-article","created":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T02:17:01Z","timestamp":1594693021000},"page":"830-837","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Considerations for the use of gonadotropin\u2010releasing hormone agonists and antagonists in patients with prostate cancer"],"prefix":"10.1111","volume":"27","author":[{"given":"Hendrik","family":"Van Poppel","sequence":"first","affiliation":[{"name":"Department of Urology University Hospital K.U. 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