{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T03:07:11Z","timestamp":1768964831062,"version":"3.49.0"},"reference-count":19,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,8,9]],"date-time":"2020-08-09T00:00:00Z","timestamp":1596931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate the prevalence of testicular microlithiasis and the relationship between testicular microlithiasis, semen parameters and endocrinological profiles in healthy newlywed men trying for first\u2010time pregnancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Men visiting Juntendo University Urayasu Hospital, Urayasu, Chiba, Japan, or D Clinic Tokyo, Chiyoda\u2010ku, Tokyo, Japan, for a first\u2010time examination of fertility underwent scrotal examination, semen analysis and blood tests. Testicular volume measured by orchidometer, semen parameters measured by the Makler counting chamber and endocrinological profiles were compared between men with testicular microlithiasis and without testicular microlithiasis. The correlation between sperm concentration and the number of calcifications, and sperm motility and the number of calcifications, were investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 739 men, 60 (8.1%) were diagnosed as having testicular microlithiasis. Among them, testicular volume, semen volume and motility were lower than those in the men without testicular microlithiasis. Luteinizing hormone and follicle\u2010stimulating hormone levels were higher in those with than those without testicular microlithiasis. The sperm concentration correlated negatively with the number of calcifications. There was no significant correlation between sperm motility and the number of calcifications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Herein, we report the prevalence of testicular microlithiasis in healthy newlywed men. Furthermore, our findings suggest that semen parameters in men with severe testicular microlithiasis tend to be worse.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iju.14342","type":"journal-article","created":{"date-parts":[[2020,8,9]],"date-time":"2020-08-09T21:32:02Z","timestamp":1597008722000},"page":"990-995","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Prevalence of testicular microlithiasis in healthy newlywed men trying for first\u2010time pregnancy"],"prefix":"10.1111","volume":"27","author":[{"given":"Ippei","family":"Hiramatsu","sequence":"first","affiliation":[{"name":"Department of Urology Juntendo University Graduate School of Medicine Bunkyo\u2010ku Tokyo Japan"},{"name":"Department of Urology Juntendo University Urayasu Hospital Urayasu Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Tsujimura","sequence":"additional","affiliation":[{"name":"Department of Urology Juntendo University Urayasu Hospital Urayasu Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miho","family":"Miyoshi","sequence":"additional","affiliation":[{"name":"Department of Urology Juntendo University Graduate School of Medicine Bunkyo\u2010ku Tokyo Japan"},{"name":"Department of Urology Juntendo University Urayasu Hospital Urayasu Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taiki","family":"Ogasa","sequence":"additional","affiliation":[{"name":"Department of Urology Juntendo University Urayasu Hospital Urayasu Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuto","family":"Miyoshi","sequence":"additional","affiliation":[{"name":"Department of Urology Juntendo University Urayasu Hospital Urayasu Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisuke","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Urology Juntendo University Graduate School of Medicine Bunkyo\u2010ku Tokyo Japan"},{"name":"Department of Urology Juntendo University Urayasu Hospital Urayasu Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuka","family":"Uesaka","sequence":"additional","affiliation":[{"name":"Department of Urology Juntendo University Urayasu Hospital Urayasu Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taiji","family":"Nozaki","sequence":"additional","affiliation":[{"name":"Department of Urology Juntendo University Urayasu Hospital Urayasu Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Shirai","sequence":"additional","affiliation":[{"name":"Department of Urology Juntendo University Urayasu Hospital Urayasu Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"D Clinic Tokyo Chiyoda\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeo","family":"Horie","sequence":"additional","affiliation":[{"name":"Department of Urology Juntendo University Graduate School of Medicine Bunkyo\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,8,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.15.15226"},{"key":"e_1_2_7_3_1","first-page":"2057","article-title":"A meta\u2010analysis of the relationship between testicular microlithiasis and incidence of testicular cancer","volume":"12","author":"Wang T","year":"2015","journal-title":"Urol. 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