{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T12:22:48Z","timestamp":1763727768385,"version":"3.45.0"},"reference-count":14,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,8,11]],"date-time":"2020-08-11T00:00:00Z","timestamp":1597104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To compare the dose evaluation parameters between conventional (using loose seed alone) and hybrid (using loose seeds in combination with stranded seeds) low\u2010dose rate brachytherapy for prostate cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Between 2014 and July 2016, a total of 219 patients who underwent low\u2010dose rate brachytherapy were enrolled in a randomized controlled trial (trial number: UMIN 000012780). Patients were randomized and allocated to two groups (conventional method\n                      <jats:italic>vs<\/jats:italic>\n                      hybrid method). Post\u2010dosimetric parameters (%D90, minimal percentage of the dose received by 90% of the prostate gland; V100, percentage of the prostate volume receiving 100% of the prescribed minimal peripheral dose; V150, percentage of the prostate volume receiving 150% of the prescribed minimal peripheral dose; %UD30, minimal percentage of the dose received by 30% of the urethra; R100, rectal volume [mL] receiving 100% of the prescribed dose) calculated at 1\u00a0month after seed implantation by computed tomography scan were compared between the two groups, as well as the post\u2010dosimetric parameters using the planning target volume of the prostate\u00a0+\u00a05\u2010mm margin.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Regarding dose evaluation parameters, the prostate dose (%D90, V100, V150) and the urethral dose (%UD30) were not significantly different between the two groups, whereas V100 (+5\u2010mm margin) and %D90 (+5\u2010mm margin) were significantly higher in the hybrid method group compared with the conventional method group (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The present randomized study shows that the hybrid method of low\u2010dose rate brachytherapy can achieve a higher coverage of the periprostatic region compared with the conventional method while maintaining an acceptable level of urethral and rectal doses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iju.14349","type":"journal-article","created":{"date-parts":[[2020,8,12]],"date-time":"2020-08-12T00:07:39Z","timestamp":1597190859000},"page":"1013-1017","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Coverage of the external prostatic region by the hybrid method compared with the conventional method of prostate low\u2010dose\u2010rate brachytherapy: A randomized controlled study"],"prefix":"10.1111","volume":"27","author":[{"given":"Nobumichi","family":"Tanaka","sequence":"first","affiliation":[{"name":"Department of Departments of Urology Nara Medical University Kashihara Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isao","family":"Asakawa","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Nara Medical University Kashihara Nara 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