{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T06:26:37Z","timestamp":1763706397432,"version":"3.45.0"},"reference-count":29,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,8,13]],"date-time":"2020-08-13T00:00:00Z","timestamp":1597276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the association between urine\u2010specific gravity and oncological outcomes in patients with non\u2010muscle\u2010invasive bladder cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We identified 433 primary non\u2010muscle\u2010invasive bladder cancer patients who underwent transurethral resection between 2002 and 2016. The association between urine\u2010specific gravity and tumor recurrence was statistically evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 211 (48.7%) patients received adjuvant bacillus Calmette\u2013Gu\u00e9rin therapy. During the median follow\u2010up period of 60\u00a0months, 155 (35.8%) patients experienced at least one tumor recurrence. Of them all, 95 (21.9%) and 338 (78.1%) patients had high (&gt;1.020) and low (\u22641.020) urine\u2010specific gravity, respectively. The Kaplan\u2013Meier curve suggested that recurrence\u2010free survival was significantly lower in patients with a high urine\u2010specific gravity; however, the multivariate analysis failed to show that urine\u2010specific gravity is significantly associated with tumor recurrence. In 222 (51.3%) patients who had not received bacillus Calmette\u2013Gu\u00e9rin therapy, the Kaplan\u2013Meier curve also suggested that recurrence\u2010free survival was significantly lower in patients with a high urine\u2010specific gravity. Multivariate analysis showed that age &gt;70\u00a0years (hazard ratio 1.69,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.02), grade\u00a03 tumor (hazard ratio 1.81,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.03) and high urine\u2010specific gravity (hazard ratio 1.87,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.01) were independent risk factors for tumor recurrence.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>High urine\u2010specific gravity is an independent risk factor for tumor recurrence in non\u2010muscle\u2010invasive bladder cancer patients who have not received bacillus Calmette\u2013Gu\u00e9rin therapy. Our results suggest that hydration status might have some clinical impacts on bladder tumor recurrence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iju.14351","type":"journal-article","created":{"date-parts":[[2020,8,13]],"date-time":"2020-08-13T22:44:58Z","timestamp":1597358698000},"page":"1019-1023","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Reduced recurrence of low\u2010risk non\u2010muscle\u2010invasive bladder cancer is associated with low urine\u2010specific gravity"],"prefix":"10.1111","volume":"27","author":[{"given":"Tomohiro","family":"Iwasawa","sequence":"first","affiliation":[{"name":"Department of Urology Tokyo Saiseikai Central Hospital Tokyo Japan"},{"name":"Department of Urology Keio University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoya","family":"Niwa","sequence":"additional","affiliation":[{"name":"Department of Urology Tokyo Saiseikai Central Hospital Tokyo Japan"},{"name":"Department of Urology Keio University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Urology Keio University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akari","family":"Komatsuda","sequence":"additional","affiliation":[{"name":"Department of Urology Tokyo Saiseikai Central Hospital Tokyo Japan"},{"name":"Department of Urology Keio University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"ide","sequence":"additional","affiliation":[{"name":"Department of Urology Tokyo Saiseikai Central Hospital Tokyo Japan"},{"name":"Department of Urology Keio University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mototsugu","family":"Oya","sequence":"additional","affiliation":[{"name":"Department of Urology Keio University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,8,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2019.08.016"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2016.06.049"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2009.06.028"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199905063401803"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25084"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwr359"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21587"},{"key":"e_1_2_8_9_1","first-page":"234","article-title":"Fluid intake and bladder cancer. 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