{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T12:12:26Z","timestamp":1780315946106,"version":"3.54.1"},"reference-count":28,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,10,3]],"date-time":"2020-10-03T00:00:00Z","timestamp":1601683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To analyze the effect and impact of low\u2010dose rituximab induction therapy on cytomegalovirus infection in living\u2010donor renal transplantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 92 recipients undergoing living\u2010donor renal transplantation at Okayama University Hospital from May 2009 to August 2018 were evaluated retrospectively. Indications for preoperative rituximab (200\u00a0mg\/body) were the following: (i) ABO major mismatch; (ii) ABO minor mismatch; (iii) donor\u2010specific anti\u2010human leukocyte antigen antibody\u2010positive; and (iv) focal segmental glomerulosclerosis. We excluded four recipients who were followed &lt;3\u00a0months, five who received &gt;200\u00a0mg\/body rituximab and seven who received prophylactic therapy for cytomegalovirus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 59 patients in the rituximab group and 17 in the non\u2010rituximab group. Groups differed significantly in age (median age 53 <jats:italic>vs<\/jats:italic> 37\u00a0years, respectively; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.04), but not in sex (male 64% <jats:italic>vs<\/jats:italic> 65%, <jats:italic>P<\/jats:italic>\u00a0=\u00a01.00), focal segmental glomerulosclerosis (3% <jats:italic>vs<\/jats:italic> 0%, <jats:italic>P<\/jats:italic>\u00a0=\u00a01.00) or percentage of cytomegalovirus\u2010seronegative recipients of renal allografts from cytomegalovirus\u2010seropositive donors (12% <jats:italic>vs<\/jats:italic> 18%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.68). The estimated glomerular filtration rate did not differ significantly between groups until 24\u00a0months after transplantation. Cytomegalovirus clinical symptoms (10% <jats:italic>vs<\/jats:italic> 24%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.22), including fever \u226538\u00b0C (5% <jats:italic>vs<\/jats:italic> 12%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.31) and gastrointestinal symptoms (5% <jats:italic>vs<\/jats:italic> 12%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.31), and the 5\u2010year survival rates of death\u2010censored graft loss (90% <jats:italic>vs<\/jats:italic> 83%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.43) did not differ significantly between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Low\u2010dose rituximab induction therapy is effective in immunological high\u2010risk recipients without increasing cytomegalovirus infection in the absence of valganciclovir prophylaxis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.14382","type":"journal-article","created":{"date-parts":[[2020,10,4]],"date-time":"2020-10-04T02:49:58Z","timestamp":1601779798000},"page":"1136-1142","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Low\u2010dose rituximab induction therapy is effective in immunological high\u2010risk renal transplantation without increasing cytomegalovirus infection"],"prefix":"10.1111","volume":"27","author":[{"given":"Kasumi","family":"Yoshinaga","sequence":"first","affiliation":[{"name":"Departments of Department of Urology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motoo","family":"Araki","sequence":"additional","affiliation":[{"name":"Departments of Department of Urology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichiro","family":"Wada","sequence":"additional","affiliation":[{"name":"Departments of Department of Urology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Maruyama","sequence":"additional","affiliation":[{"name":"Departments of Department of Urology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosuke","family":"Mitsui","sequence":"additional","affiliation":[{"name":"Departments of Department of Urology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Sadahira","sequence":"additional","affiliation":[{"name":"Departments of Department of Urology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Risa","family":"Kubota","sequence":"additional","affiliation":[{"name":"Departments of Department of Urology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shingo","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Departments of Department of Urology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuyuki","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Departments of Department of Urology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidemi","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Rheumatology, Endocrinology and Metabolism Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuyuki","family":"Tanabe","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Rheumatology, Endocrinology and Metabolism Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Kitagawa","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Rheumatology, Endocrinology and Metabolism Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Morinaga","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Rheumatology, Endocrinology and Metabolism Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruhito Adam","family":"Uchida","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Rheumatology, Endocrinology and Metabolism Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Kitamura","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Rheumatology, Endocrinology and Metabolism Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Sugiyama","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Rheumatology, Endocrinology and Metabolism Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Wada","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Rheumatology, Endocrinology and Metabolism Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masami","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Departments of Department of Urology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toyohiko","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Departments of Department of Urology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasutomo","family":"Nasu","sequence":"additional","affiliation":[{"name":"Departments of Department of Urology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2018.01.002"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-019-02113-z"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2011.03686.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2013.03.022"},{"key":"e_1_2_8_6_1","first-page":"89","article-title":"Annual progress report from the Japanese renal transplant registry: number of renal transplantations in 2017 and a follow\u2010up survey","volume":"53","author":"Japan Society for Transplantation","year":"2018","journal-title":"J. Jpn. Soc. Clin. Ren. Transpl."},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/tri.12072"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200211150-00001"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/0886022X.2015.1077310"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181a235fd"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31820f08e8"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0012.2010.01384.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2012.244"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.62.suppl_2.ii55"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1053\/sonc.2003.50025"},{"key":"e_1_2_8_16_1","first-page":"295","article-title":"The efficacy of rituximab in high\u2010risk renal transplant recipients","volume":"70","author":"Araki M","year":"2016","journal-title":"Acta Med. Okayama"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2006.01497.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2010.11.005"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2008.00821.x"},{"key":"e_1_2_8_20_1","first-page":"7","article-title":"Prevention of acute antibody\u2010mediated rejection in anti\u2010donor antibody\u2010positive patients at TWMUH \uf8ffBeyond HLA\uf8ff","volume":"7","author":"Ishida H","year":"2019","journal-title":"J. Jpn. Soc. Clin. Ren. Transpl."},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2004.00454.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0012.2008.00902.x"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000078622.43689.D4"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/1744-9987.12483"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2002.00026.x"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2002.tb00192.x"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-008-0113-y"},{"key":"e_1_2_8_28_1","first-page":"147","article-title":"Renal graft irradiation in ABO\u2010mismatched renal transplantation","volume":"64","author":"Matsushita H","year":"2016","journal-title":"Shinshu Med. J."},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181dc0999"}],"container-title":["International Journal of Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iju.14382","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/iju.14382","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iju.14382","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T19:36:23Z","timestamp":1693856183000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iju.14382"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,3]]},"references-count":28,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1111\/iju.14382"],"URL":"https:\/\/doi.org\/10.1111\/iju.14382","archive":["Portico"],"relation":{},"ISSN":["0919-8172","1442-2042"],"issn-type":[{"value":"0919-8172","type":"print"},{"value":"1442-2042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,3]]},"assertion":[{"value":"2020-06-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}