{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T16:42:54Z","timestamp":1791650574671,"version":"4.3.4"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,11,9]],"date-time":"2020-11-09T00:00:00Z","timestamp":1604880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To identify the prognosis of patients with non\u2010urothelial carcinoma of the upper urinary tract and compare it with that of patients with urothelial carcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used hospital\u2010based cancer registry data in Japan to extract histologically confirmed non\u2010urothelial carcinoma and urothelial carcinoma cases of the upper urinary tract diagnosed in 2008\u20132009. We estimated the 5\u2010year overall survival by a Kaplan\u2013Meier analysis. The Cox proportional hazards regression analysis was used to evaluate prognostic factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 2567 upper urinary tract cancer patients with confirmed histological subtypes were identified. The most common histology of non\u2010urothelial carcinoma was squamous cell carcinoma (<jats:italic>n<\/jats:italic>\u00a0=\u00a088, 3.4%) followed by adenocarcinoma (<jats:italic>n<\/jats:italic>\u00a0=\u00a033, 1.3%) and small cell carcinoma (<jats:italic>n<\/jats:italic>\u00a0=\u00a010, 0.4%). The proportion of advanced stage in the squamous cell carcinoma patients was significantly higher than that in the urothelial carcinoma patients (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.003). In stage\u00a0IV, the proportion of patients who received a combination of surgery\u00a0+\u00a0chemotherapy in the urothelial carcinoma group was higher than that in the non\u2010urothelial carcinoma group (34% <jats:italic>vs<\/jats:italic> 16%, respectively). The 5\u2010year overall survival rates of the non\u2010urothelial carcinoma patients at stages\u00a0I\u2013III and stage\u00a0IV were significantly worse than those of the urothelial carcinoma patients (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.003, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001, respectively). In multivariate analyses, age \u226573\u00a0years, advanced stage (stage\u00a0IV), tumor location (ureter) and the presence of non\u2010urothelial carcinoma histology were independent poor prognosis factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The prognosis of non\u2010urothelial carcinoma patients is worse than that of urothelial carcinoma patients, especially for non\u2010urothelial carcinoma patients at stage\u00a0IV. More effective systemic therapies are required to improve these patients\u2019 oncological outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.14393","type":"journal-article","created":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T00:49:55Z","timestamp":1604969395000},"page":"54-60","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Prognostic impact of non\u2010urothelial carcinoma of the upper urinary tract: Analysis of hospital\u2010based cancer registry data in Japan"],"prefix":"10.1111","volume":"28","author":[{"given":"Yoshiyuki","family":"Nagumo","sequence":"first","affiliation":[{"name":"Department of Urology University of Tsukuba Tsukuba Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Kawai","sequence":"additional","affiliation":[{"name":"Department of Urology International University of Health and Welfare Narita Chiba 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