{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T13:30:33Z","timestamp":1790602233620,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,3,20]],"date-time":"2021-03-20T00:00:00Z","timestamp":1616198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To develop a simple score for predicting vesicoureteral reflux after a first febrile urinary tract infection in children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cohort study was conducted for a 12\u2010year period (January 2008 to December 2019), including patients aged &lt;72\u00a0months who underwent renal ultrasonography and voiding cystourethrography after a first febrile urinary tract infection. Patients with a history of antenatal hydronephrosis were excluded. The prediction model and score for vesicoureteral reflux were developed using multivariate logistic regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of 260 patients in total (median age 4\u00a0months, 172 boys), 41 (16%) had vesicoureteral reflux. The score was based on four independent risk factors, including age &gt;6\u00a0months (odds ratio 2.71, 95% confidence interval 1.27\u20135.76), presence of sepsis (odds ratio 3.44, 95% confidence interval 1.31\u20139.04), white blood cell count \u226515\u00a0000\/mm<jats:sup>3<\/jats:sup> (odds ratio\u00a01.83, 95% confidence interval 0.88\u20133.8) and abnormal renal ultrasonography results (odds ratio\u00a02.08, 95% confidence interval 1\u20134.31). A lower probability of vesicoureteral reflux (positive likelihood ratio\u00a0=\u00a00.66; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001) was found in the low\u2010risk group (scores 0\u20132), whereas a higher probability of vesicoureteral reflux (positive likelihood ratio\u00a0=\u00a02.54; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001) was found in the high\u2010risk group (scores 3\u20135). The predictive ability of the model was 70%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The scores developed based on the patient characteristics and renal ultrasonography are useful in predicting presence of vesicoureteral reflux after a first febrile urinary tract infection in children and could guide clinicians' decisions to perform additional imaging studies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.14515","type":"journal-article","created":{"date-parts":[[2021,3,21]],"date-time":"2021-03-21T00:46:16Z","timestamp":1616287576000},"page":"573-577","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Predictive score for vesicoureteral reflux in children with a first febrile urinary tract infection"],"prefix":"10.1111","volume":"28","author":[{"given":"Kanita","family":"Lertdumrongluk","sequence":"first","affiliation":[{"name":"Department of Paediatrics Charoenkrung Pracharak Hospital, Bangkok Metropolitan Administration Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paungpaga","family":"Lertdumrongluk","sequence":"additional","affiliation":[{"name":"Panyananthaphikkhu Chonprathan Medical Center, Srinakharinwirot University Nonthaburi Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/20469047.2017.1382046"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1007755"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60383-4"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2001.118188"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.105.4.e50"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.2005.036327"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2010.03.076"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.5152\/tud.2016.56750"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.18.2.417-422.2005"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2004.068205"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2016-311587"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2016-3026"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.4103\/0256-4947.51817"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2013.04.026"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-2109"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2015.03.010"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedneo.2015.06.001"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2000.tb00380.x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-006-0418-6"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021698"},{"key":"e_1_2_8_22_1","first-page":"24","article-title":"Urinary tract infection and vesicoureteral reflux in Saudi children","volume":"13","author":"Al\u2010Ibrahim AA","year":"2002","journal-title":"Saudi J. 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