{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T23:24:48Z","timestamp":1785108288969,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,3,4]],"date-time":"2021-03-04T00:00:00Z","timestamp":1614816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the efficacy of intraprostatic injection of prophylactic antibiotics for the prevention of infections following transrectal ultrasonography\u2010guided prostate biopsy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this prospective interventional study, patients aged between 40 and 70\u00a0years with clinical indications for transrectal ultrasonography\u2010guided prostate biopsy were enrolled. Consecutive patients who received intraprostatic injection of amikacin coupled with oral ciprofloxacin were compared with historical controls receiving only prophylactic oral fluoroquinolones prior to biopsy. Patients were followed for 7\u00a0days after biopsy for signs and symptoms of infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 210 patients were included in this study (mean age 65.7\u00a0\u00b1\u00a07.8\u00a0years). Among patients without intraprostatic injection, nine (8.6%) developed infectious complications (lower urinary tract infection in seven patients, and prostatitis in two), which led to hospitalization in six patients (5.7%). None of the patients who received intraprostatic antibiotic injection developed infectious complications. The difference in the incidence of post\u2010transrectal ultrasonography\u2010guided biopsy infections between the two groups was statistically significant (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.003).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Local intraprostatic antibiotic injection during transrectal ultrasonography\u2010guided prostate biopsy adjuvant to oral fluoroquinolones can significantly reduce the rate of post\u2010biopsy infectious complications.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.14541","type":"journal-article","created":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T07:50:25Z","timestamp":1614930625000},"page":"683-686","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Intraprostatic prophylactic antibiotic injection in patients undergoing transrectal ultrasonography\u2010guided prostate biopsy"],"prefix":"10.1111","volume":"28","author":[{"given":"Farzaneh","family":"Shobeirian","sequence":"first","affiliation":[{"name":"Razi Clinical Research Development Unit Razi Hospital Guilan University of Medical Sciences Rasht Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikan","family":"Zerafatjou","sequence":"additional","affiliation":[{"name":"Department of Urology Shahid Rajaee Hospital Isfahan University of Medical Sciences Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Ghomi","sequence":"additional","affiliation":[{"name":"Department of Radiology Shohada\u2010E\u2010Tajrish Hospital Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad","family":"Vafaei","sequence":"additional","affiliation":[{"name":"Radiology Ward Borazjan Hospital Bushehr University of Medical Science Bushehr Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohsen","family":"Darabi","sequence":"additional","affiliation":[{"name":"Department of Radiology Hasheminejad Hospital Iran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12894-016-0169-z"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2016.08.004"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.4111\/kju.2015.56.6.466"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/1533034617722080"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2016.12.011"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.13402"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-018-2217-7"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0170319"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4160-6911-9.00010-4"},{"key":"e_1_2_7_11_1","first-page":"183","article-title":"Factors affecting complications of transrectal ultrasound\u2010guided prostate biopsy: a cohort study with 403 patients in a single center","volume":"3","author":"K\u00f6l\u00fck\u00e7\u00fc E","year":"2019","journal-title":"J. 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