{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T22:42:34Z","timestamp":1759963354517,"version":"3.40.5"},"reference-count":14,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,3,18]],"date-time":"2021-03-18T00:00:00Z","timestamp":1616025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the clinical outcomes of highest\u2010risk non\u2010muscle\u2010invasive bladder cancer patients treated with intravesical bacillus Calmette\u2013Gu\u00e9rin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The medical charts of patients with non\u2010muscle\u2010invasive bladder cancer treated with intravesical bacillus Calmette\u2013Gu\u00e9rin between 2000 and 2018 at a single institution were retrospectively reviewed. Patients were stratified into three groups (intermediate\u2010, high\u2010 and highest\u2010risk groups) according to the risk classification of the updated Japanese Urological Association guidelines 2019. Among the three groups, the intravesical recurrence\u2010free survival and progression\u2010free survival were estimated and compared, respectively. Furthermore, the different types of risk factors in the highest\u2010risk group were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 165 patients, 49 (30%) patients had intravesical recurrence and 23 (14%) patients showed progression to muscle\u2010invasive disease during a median follow\u2010up period of 53\u00a0months. Significant differences were not noted in the recurrence\u2010free survival and progression\u2010free survival among the three groups. Multivariable survival analysis of 74 patients in the highest\u2010risk group showed that carcinoma <jats:italic>in\u00a0situ<\/jats:italic> in the prostatic urethra was a significant predictor associated with recurrence (hazard ratio 3.20, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.026) and progression (hazard ratio 4.36, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.013).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Intravesical bacillus Calmette\u2013Gu\u00e9rin can control highest\u2010risk non\u2010muscle\u2010invasive bladder cancer in most patients. Our findings might aid in decision\u2010making regarding the treatment of this subset of patients who require intensive treatment, such as intravesical therapy with bacillus Calmette\u2013Gu\u00e9rin and radical cystectomy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.14545","type":"journal-article","created":{"date-parts":[[2021,3,18]],"date-time":"2021-03-18T09:36:17Z","timestamp":1616060177000},"page":"720-726","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Clinical outcomes after intravesical bacillus Calmette\u2013Gu\u00e9rin for the highest\u2010risk non\u2010muscle\u2010invasive bladder cancer newly defined in the Japanese Urological Association Guidelines 2019"],"prefix":"10.1111","volume":"28","author":[{"given":"Tatsuki","family":"Miyamoto","sequence":"first","affiliation":[{"name":"Departments of Department of Urology and Nara Medical University Kashihara Nara 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