{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T13:44:16Z","timestamp":1789047856656,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,5,19]],"date-time":"2021-05-19T00:00:00Z","timestamp":1621382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the safety and outcomes between green\u2010light laser en bloc resection and transurethral resection of bladder tumor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A single\u2010center, randomized controlled trial was carried out from August 2014 to September 2018. Patients with initial non\u2010muscle\u2010invasive bladder cancer were randomized to green\u2010light laser en bloc resection or transurethral resection of bladder tumor. The primary outcomes were pathological findings and perioperative events. The secondary outcome was tumor recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 233 patients were randomized to the transurethral resection of bladder tumor group (117 patients) and the green\u2010light laser en bloc resection group (116 patients). The resection time was longer in the green\u2010light laser en bloc resection group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.022); however, no differences were identified in overall operative time (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.255). Nine patients (7.7%) had an obturator nerve reflex during transurethral resection of bladder tumor. The estimated volume of blood loss was significantly lower in the green\u2010light laser en bloc resection group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.012). The green\u2010light laser en bloc resection group had a higher rate of T1 bladder cancer (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.031). A total of 104 patients (89.7%) treated with green\u2010light laser en bloc resection had detrusor muscle presence in the specimen, whereas 37 (31.9%) patients had the presence of muscularis mucosae, which was significantly higher than the corresponding number of transurethral resection of bladder tumor patients (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.005 and 0.002, respectively). After a median follow\u2010up period of 48\u00a0months, just five patients had tumor recurrence (three in the transurethral resection of bladder tumor group and two in the green\u2010light laser en bloc resection group), and there was no difference between these two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Compared with transurethral resection of bladder tumor, green\u2010light laser en bloc resection is more effective due to less obturator nerve reflex and the same recurrence rate. Most importantly, green\u2010light laser en bloc resection can provide better tumor specimens for pathological examinations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.14592","type":"journal-article","created":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T00:36:15Z","timestamp":1621470975000},"page":"855-860","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Green\u2010light laser en bloc resection versus conventional transurethral resection for initial non\u2010muscle\u2010invasive bladder cancer: A randomized controlled trial"],"prefix":"10.1111","volume":"28","author":[{"given":"Jinhai","family":"Fan","sequence":"first","affiliation":[{"name":"Department of Urology First Affiliated Hospital of Xi\u2019an Jiaotong University Xi\u2019an, Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaijie","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Urology First Affiliated Hospital of Xi\u2019an Jiaotong University Xi\u2019an, Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Urology First Affiliated Hospital of Xi\u2019an Jiaotong University Xi\u2019an, Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Urology First Affiliated Hospital of Xi\u2019an Jiaotong University Xi\u2019an, Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Urology First Affiliated Hospital of Xi\u2019an Jiaotong University Xi\u2019an, Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumei","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Urology First Affiliated Hospital of Xi\u2019an Jiaotong University Xi\u2019an, Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojing","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Urology First Affiliated Hospital of Xi\u2019an Jiaotong University Xi\u2019an, Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Urology First Affiliated Hospital of Xi\u2019an Jiaotong University Xi\u2019an, Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalin","family":"He","sequence":"additional","affiliation":[{"name":"Department of Urology First Affiliated Hospital of Xi\u2019an Jiaotong University Xi\u2019an, Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOU.0000000000000542"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-019-02805-8"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-014-1337-y"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2010.03.007"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euf.2016.12.004"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2020.05.042"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2014.23"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23202"},{"key":"e_1_2_8_10_1","first-page":"309","article-title":"Safety and efficacy of 120W high performance system greenlight laser vaporization for non\u2010muscle\u2010invasive bladder cancer","volume":"21","author":"Tao W","year":"2013","journal-title":"J. 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