{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T19:25:08Z","timestamp":1768418708513,"version":"3.49.0"},"reference-count":20,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the efficacy and safety of botulinum toxin treatment (onabotulinumtoxinA 200\u00a0units) for Japanese patients with neurogenic detrusor overactivity caused by spinal cord injury or multiple sclerosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with urinary incontinence refractory to pharmacological treatment were enrolled and randomized in a phase\u00a0III trial. A single dose of onabotulinumtoxinA (<jats:italic>n<\/jats:italic>\u00a0=\u00a011) or placebo (<jats:italic>n<\/jats:italic>\u00a0=\u00a010) was given in the double\u2010blind phase, and repeat injections of onabotulinumtoxinA were given in the subsequent open\u2010label phase. Outcomes included urinary incontinence episodes, urodynamics, patient\u2010reported outcomes and adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The onabotulinumtoxinA group showed a numerically greater reduction in the number of urinary incontinence episodes per day than the placebo group, with the difference between the groups at week\u00a06 of \u22123.02 (95% confidence interval \u22125.85 to \u22120.19). The onabotulinumtoxinA group also showed greater improvements in urodynamic assessments. Adverse events related to onabotulinumtoxinA injections were hematuria, urinary retention, urinary bladder hemorrhage, autonomic dysreflexia and epididymitis. Most events were deemed mild or moderate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Intradetrusor injections of onabotulinumtoxinA are efficacious and tolerable for Japanese patients with neurogenic detrusor overactivity\u2010related symptoms that are difficult to manage with anticholinergics and\/or \u03b2<jats:sub>3<\/jats:sub>\u2010adrenergic receptor agonists.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.14602","type":"journal-article","created":{"date-parts":[[2021,6,2]],"date-time":"2021-06-02T02:58:05Z","timestamp":1622602685000},"page":"906-912","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Botulinum toxin injections for Japanese patients with urinary incontinence caused by neurogenic detrusor overactivity: Clinical evaluation of onabotulinumtoxinA in a randomized, placebo\u2010controlled, double\u2010blind trial with an open\u2010label extension"],"prefix":"10.1111","volume":"28","author":[{"given":"Masashi","family":"Honda","sequence":"first","affiliation":[{"name":"Department of Urology Tottori University Faculty of Medicine Yonago Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Yokoyama","sequence":"additional","affiliation":[{"name":"Department of Urology Faculty of Medical Science University of Fukui Fukui Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryosuke","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Urology Spinal Injuries Center Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuma","family":"Matsuda","sequence":"additional","affiliation":[{"name":"Clinical Development (Oncology) Japan Medical and Development GlaxoSmithKline K.K. Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Biostatistics Japan Medical and Development GlaxoSmithKline K.K. Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takao","family":"Mogi","sequence":"additional","affiliation":[{"name":"Clinical Development (Specialty) Japan Medical and Development GlaxoSmithKline K.K. Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-11-13"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2007.04.026"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-14-74"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2008.08.048"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.21003"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2005.12.010"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2011.07.002"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.01.125"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2012.11.010"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.23027"},{"key":"e_1_2_10_12_1","unstructured":"BlokB PannekJ Castro\u2010DiazDet\u00a0al.EAU guidelines on neuro\u2010urology. European Association of Urology.2017."},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.12668"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2008.05.033"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2042.2012.03218.x"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2009.04.028"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2044.1998.00337.x"},{"key":"e_1_2_10_18_1","volume-title":"Acute management of autonomic dysreflexia: individuals with spinal cord injury presenting to health\u2010care facilities","author":"Consortium for Spinal Cord Medicine","year":"2001"},{"key":"e_1_2_10_19_1","first-page":"931","article-title":"Rehabilitation medicine: 1","volume":"169","author":"Blackmer J","year":"2003","journal-title":"Autonomic dysreflexia. CMAJ."},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000132152.53532.5d"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-013-0054-z"}],"container-title":["International Journal of Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iju.14602","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/iju.14602","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iju.14602","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T16:42:52Z","timestamp":1693327372000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iju.14602"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":20,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1111\/iju.14602"],"URL":"https:\/\/doi.org\/10.1111\/iju.14602","archive":["Portico"],"relation":{},"ISSN":["0919-8172","1442-2042"],"issn-type":[{"value":"0919-8172","type":"print"},{"value":"1442-2042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"2020-11-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}