{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T16:39:33Z","timestamp":1772555973819,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,5,29]],"date-time":"2021-05-29T00:00:00Z","timestamp":1622246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the mid\u2010term efficacy and safety of anterior urethroplasty using an autologous tissue\u2010engineered oral mucosa graft (MukoCell<jats:sup>\u00ae<\/jats:sup>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The data of 77 patients with anterior urethral strictures undergoing treatment with MukoCell<jats:sup>\u00ae<\/jats:sup> at a tertiary center from June 2016 to May 2019 were analyzed. Patients\u2019 characteristics, pre\u2010 and postoperative diagnostics, perioperative complications, and follow\u2010up data were obtained. The overall stricture\u2010free survival, outcomes of the different surgical techniques, stricture localizations, stricture length, early complications of the procedure and risk factors of recurrence were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median follow\u2010up period was 38\u00a0months (interquartile range 31\u201346). The overall recurrence\u2010free rate of anterior urethroplasty using MukoCell<jats:sup>\u00ae<\/jats:sup> was 68.8%, 24 patients (31.2%) developed a recurrence of the stricture. The stricture recurrences were observed at a median of 7\u00a0months (interquartile range 3\u201313) only in patients with at least one previous surgery or repeated dilatations in their medical history. No oral\u2010urethral adverse events related to the use of MukoCell<jats:sup>\u00ae<\/jats:sup> were observed, except for a urethrocutaneous fistula (1.3%) requiring reoperation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Anterior one\u2010stage urethroplasty using MukoCell<jats:sup>\u00ae<\/jats:sup> showed in our hands a mid\u2010term success rate of up to 68.8% without significant adverse events after a median follow\u2010up period of 38\u00a0months. This procedure might be an alternative option for long\u2010segment urethral reconstruction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.14606","type":"journal-article","created":{"date-parts":[[2021,5,30]],"date-time":"2021-05-30T00:59:27Z","timestamp":1622336367000},"page":"936-942","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Safety and mid\u2010term surgical results of anterior urethroplasty with the tissue\u2010engineered oral mucosa graft MukoCell<sup>\u00ae<\/sup>: A single\u2010center experience"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7608-7673","authenticated-orcid":false,"given":"Leonidas","family":"Karapanos","sequence":"first","affiliation":[{"name":"Department of Urology, Uro\u2010Oncology, Robot\u2010Assisted and Reconstructive Surgery Faculty of Medicine and University Hospital Cologne University of Cologne Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1487-8696","authenticated-orcid":false,"given":"Ilgar","family":"Akbarov","sequence":"additional","affiliation":[{"name":"Department of Urology, Uro\u2010Oncology, Robot\u2010Assisted and Reconstructive Surgery Faculty of Medicine and University Hospital Cologne University of Cologne Cologne Germany"},{"name":"Department of Urology University Hospital Basel Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vahudin","family":"Zugor","sequence":"additional","affiliation":[{"name":"Department of Urology, Uro\u2010Oncology, Robot\u2010Assisted and Reconstructive Surgery Faculty of Medicine and University Hospital Cologne University of Cologne Cologne Germany"},{"name":"Department of Urology Sozialstiftung Bamberg Bamberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0462-1045","authenticated-orcid":false,"given":"Ruud","family":"Kokx","sequence":"additional","affiliation":[{"name":"Department of Urology, Uro\u2010Oncology, Robot\u2010Assisted and Reconstructive Surgery Faculty of Medicine and University Hospital Cologne University of Cologne Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8795-7352","authenticated-orcid":false,"given":"Anna","family":"Hagemeier","sequence":"additional","affiliation":[{"name":"Institute of Medical Statistics and Computational Biology Medical Faculty University of Cologne Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2511-3664","authenticated-orcid":false,"given":"Axel","family":"Heidenreich","sequence":"additional","affiliation":[{"name":"Department of Urology, Uro\u2010Oncology, Robot\u2010Assisted and Reconstructive Surgery Faculty of Medicine and University Hospital Cologne University of Cologne Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,5,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)36054-8"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2007.05.033"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2011.02.010"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2013.09.006"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2015.07.098"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.13528"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199008233230806"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)35728-2"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2008.01.061"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2014.11.009"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2017.08.014"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2018.02.3102"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.1994.tb16553.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(96)00154-9"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410X.1996.23121.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(01)01377-2"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2011.10787.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000069820.81726.00"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2009.10.018"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2010.09800.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2011.12.074"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2010.04.013"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2010.118"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.07.101"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2017.05.006"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2014.02.492"}],"container-title":["International Journal of Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iju.14606","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/iju.14606","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iju.14606","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T20:42:45Z","timestamp":1693341765000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iju.14606"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,29]]},"references-count":26,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1111\/iju.14606"],"URL":"https:\/\/doi.org\/10.1111\/iju.14606","archive":["Portico"],"relation":{},"ISSN":["0919-8172","1442-2042"],"issn-type":[{"value":"0919-8172","type":"print"},{"value":"1442-2042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,29]]},"assertion":[{"value":"2021-01-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}