{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T08:14:46Z","timestamp":1790151286422,"version":"4.0.1"},"reference-count":22,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T00:00:00Z","timestamp":1624492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate whether the efficacy of desmopressin differs between patients with and without nocturnal polyuria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 65 treatment\u2010na\u00efve children with monosymptomatic nocturnal enuresis were enrolled (45 boys; median age 8.9\u00a0years). Patients received desmopressin as their first\u2010line treatment. Four different standards were used (Akashi and Hoashi &gt;0.9\u00a0mL\/kg\/sleeping hour; Hamano &gt;[age\u00a0+\u00a02]\u00a0\u00d7\u00a025\u00a0\u00d7\u00a0130% mL; the International Children's Continence Society &gt;[age\u00a0+\u00a01]\u00a0\u00d7\u00a030\u00a0\u00d7\u00a0130% mL; and Rittig &gt;[age\u00a0+\u00a09]\u00a0\u00d7\u00a020\u00a0mL) to assess nocturnal polyuria. The effectiveness of desmopressin was compared between patients with and without nocturnal polyuria according to each standard. A response was defined as a reduction in wet nights of &gt;50%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The desmopressin treatment efficacy rate was 54% for polyuria and 67% for non\u2010polyuria patients (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.20), 45% for polyuria and 68% for non\u2010polyuria patients (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.08), 54% for polyuria and 59% for non\u2010polyuria patients (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.80), and 52% for polyuria and 61% for non\u2010polyuria patients (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.61), for the Akashi and Hoashi's, Hamano's, International Children\u2019s Continence Society and Rittig's standards, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>No difference was observed in the short\u2010term clinical efficacy of desmopressin regardless of the presence of nocturnal polyuria. Thus, this might be a feasible treatment option for patients with nocturnal enuresis without nocturnal polyuria.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.14615","type":"journal-article","created":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T00:32:47Z","timestamp":1624581167000},"page":"964-968","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Desmopressin response in nocturnal enuresis without nocturnal polyuria in Japanese children"],"prefix":"10.1111","volume":"28","author":[{"given":"Shohei","family":"Akagawa","sequence":"first","affiliation":[{"name":"Department of Pediatrics Kansai Medical University Hirakata Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoji","family":"Tsuji","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kansai Medical University Hirakata Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Akagawa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kansai Medical University Hirakata Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sohsaku","family":"Yamanouchi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kansai Medical University Hirakata Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahisa","family":"Kimata","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kansai Medical University Hirakata Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazunari","family":"Kaneko","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kansai Medical University Hirakata Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1988.tb10614.x"},{"key":"e_1_2_8_3_1","first-page":"F664","article-title":"Abnormal diurnal rhythm of plasma vasopressin and urinary output in patients with enuresis","volume":"256","author":"Rittig S","year":"1989","journal-title":"Am. 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