{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T07:07:03Z","timestamp":1776928023966,"version":"3.51.2"},"reference-count":22,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,7,17]],"date-time":"2021-07-17T00:00:00Z","timestamp":1626480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["18K16751"],"award-info":[{"award-number":["18K16751"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the effect of vibegron, a new clinically approved \u03b23\u2010adrenoceptor agonist in lower urinary tract dysfunction in mice with spinal cord injury.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Investigators performed cystometry under awake conditions in 4\u2010week spinal cord injury female mice. Two weeks after spinal cord injury, saline or vibegron (30\u00a0mg\/kg) was orally administered for 2\u00a0weeks prior to the urodynamic study. Investigators removed L6\u2010S1 dorsal root ganglia from the saline\u2010 or vibegron\u2010treated spinal cord injury mice as well as from saline\u2010treated normal (spinal intact) mice to evaluate the levels of transient receptor potential cation channel subfamily V member 1, transient receptor potential cation channel subfamily A member 1, activating transcription factor 3, and inducible nitric oxide synthase transcripts using real\u2010time polymerase chain reaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In vibegron\u2010treated spinal cord injury mice, nonvoiding contractions during bladder filling, which were increased in spinal cord injury compared to spinal intact mice, were significantly decreased. Micturition pressure or voiding efficiency was not significantly increased in comparison to measurements in saline\u2010treated spinal cord injury mice. The expression of transient receptor potential cation channel subfamily V member 1, transient receptor potential cation channel subfamily A member 1, activating transcription factor 3, and inducible nitric oxide synthase messenger RNA was increased in spinal cord injury mice compared to spinal intact mice, but significantly decreased after vibegron treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Vibegron improves spinal cord injury\u2010induced detrusor overactivity in addition to significantly reducing C\u2010fiber afferent receptors such as transient receptor potential cation channel subfamily V member 1, transient receptor potential cation channel subfamily A member 1, and inflammatory cytokines\/markers, such as activating transcription factor 3 and inducible nitric oxide synthase, in spinal cord injury mice. Thus, vibegron might be effective in the treatment of storage lower urinary tract dysfunction induced by C\u2010fiber afferent activation after spinal cord injury.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.14630","type":"journal-article","created":{"date-parts":[[2021,7,17]],"date-time":"2021-07-17T07:39:25Z","timestamp":1626507565000},"page":"1068-1072","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Efficacy of vibegron, a novel \u03b23\u2010adrenoreceptor agonist, for lower urinary tract dysfunction in mice with spinal cord injury"],"prefix":"10.1111","volume":"28","author":[{"given":"Nobutaka","family":"Shimizu","sequence":"first","affiliation":[{"name":"Department of Urology Kindai University Faculty of Medicine Osakasayama Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Gotoh","sequence":"additional","affiliation":[{"name":"Department of Urology University of Pittsburgh Pittsburgh PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuhisa","family":"Nishimoto","sequence":"additional","affiliation":[{"name":"Department of Urology Kindai University Faculty of Medicine Osakasayama Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamoru","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Urology Kindai University Faculty of Medicine Osakasayama Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuichi","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Urology University of Pittsburgh Pittsburgh PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazutoshi","family":"Fujita","sequence":"additional","affiliation":[{"name":"Department of Urology Kindai University Faculty of Medicine Osakasayama Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihide","family":"Hirayama","sequence":"additional","affiliation":[{"name":"Department of Urology Kindai University Nara Hospital Ikoma, Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Yoshimura","sequence":"additional","affiliation":[{"name":"Department of Urology University of Pittsburgh Pittsburgh PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirotsugu","family":"Uemura","sequence":"additional","affiliation":[{"name":"Department of Urology Kindai University Faculty of Medicine Osakasayama Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,7,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2011.05.003"},{"key":"e_1_2_9_3_1","first-page":"327","article-title":"Neural control of the lower urinary tract","volume":"5","author":"Groat WC","year":"2015","journal-title":"Compr. 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