{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:36:17Z","timestamp":1790832977826,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,7,13]],"date-time":"2021-07-13T00:00:00Z","timestamp":1626134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To prospectively assess the efficacy and safety of <jats:italic>Lactobacillus<\/jats:italic> vaginal suppositories for the prevention of recurrent cystitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this single\u2010arm, open\u2010label, phase\u00a0II clinical trial, participants used vaginal suppositories containing the GAI 98322 strain of <jats:italic>Lactobacillus<\/jats:italic> <jats:italic>crispatus<\/jats:italic> for 1\u00a0year either every 2\u00a0days or three times per week. The primary end\u2010point was the response rate, as assessed by the number of episodes of recurrent cystitis during the year of administration. The secondary end\u2010points were the response rate, as assessed by episodes of recurrent cystitis during the 1\u00a0year after completion of the administration period; the total number of episodes of recurrent cystitis before, during and after administration; adverse events; and changes in urine bacteria and the vaginal microbiome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 28 women were enrolled, and 21 completed the study. A total of 18 patients achieved an effective response (86%) during administration. The suppressive effects of <jats:italic>Lactobacillus<\/jats:italic> vaginal suppositories on episodes of cystitis continued up to 1\u00a0year after the last suppository was administered. There was a significant reduction in the mean number of episodes of cystitis, both during and after administration of <jats:italic>Lactobacillus<\/jats:italic> vaginal suppositories. No treatment\u2010related adverse events were observed. Amplicon sequencing analysis of the vaginal microbiome showed that <jats:italic>Lactobacillus<\/jats:italic> species colonized the vagina during the periods when episodes of cystitis were absent.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Vaginal suppositories containing the GAI 98322 strain of <jats:italic>Lactobacillus<\/jats:italic> <jats:italic>crispatus<\/jats:italic> effectively prevent episodes of recurrent cystitis, both during administration and for at least 1\u00a0year after administration.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.14636","type":"journal-article","created":{"date-parts":[[2021,7,14]],"date-time":"2021-07-14T02:50:45Z","timestamp":1626231045000},"page":"1026-1031","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Efficacy of <i>Lactobacillus<\/i> vaginal suppositories for the prevention of recurrent cystitis: A phase\u00a0II clinical trial"],"prefix":"10.1111","volume":"28","author":[{"given":"Takuya","family":"Sadahira","sequence":"first","affiliation":[{"name":"Department of Urology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichiro","family":"Wada","sequence":"additional","affiliation":[{"name":"Department of Urology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motoo","family":"Araki","sequence":"additional","affiliation":[{"name":"Department of Urology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritsuko","family":"Mitsuhata","sequence":"additional","affiliation":[{"name":"Department of Urology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masumi","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Urology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Maruyama","sequence":"additional","affiliation":[{"name":"Department of Urology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takehiro","family":"Iwata","sequence":"additional","affiliation":[{"name":"Department of Urology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masami","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Urology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toyohiko","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Urology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reiko","family":"Kariyama","sequence":"additional","affiliation":[{"name":"Department of Urology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan"},{"name":"Department of Food and Nutrition Okayama Gakuin University Kurashiki Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasutomo","family":"Nasu","sequence":"additional","affiliation":[{"name":"Department of Urology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayano","family":"Ishii","sequence":"additional","affiliation":[{"name":"Department of Urology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,13]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"BonkatG BarotolettiR BruyereFet\u00a0al.Guidelines on urological Infections. 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