{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T16:37:28Z","timestamp":1785515848757,"version":"3.56.0"},"reference-count":28,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T00:00:00Z","timestamp":1628553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Henoch\u2013Sch\u00f6nlein purpura nephritis has become a significant threat to children's health. Traditional combined therapy of glucocorticoids and cyclophosphamide leads to severe toxicity and complications. Therefore, identifying a feasible and effective strategy with low side\u2010effects for the treatment of Henoch\u2013Sch\u00f6nlein purpura nephritis is of great significance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A randomized, controlled trial was carried out. A total of 279 children with Henoch\u2013Sch\u00f6nlein purpura nephritis were recruited and randomly divided into three groups: control group (receiving the current standard therapy), TA group (receiving tacrolimus) and TA\u00a0+\u00a0tripterygium glycosides group (receiving tacrolimus\u00a0+\u00a0tripterygium treatment). The total duration of the trial was 6\u00a0months, and the duration of follow\u2010up observation was 9\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Various therapies showed similar therapeutic effects in the third and sixth months. The relief of Henoch\u2013Sch\u00f6nlein purpura nephritis symptoms caused by TA\u00a0+\u00a0tripterygium glycosides was slower than the TA and control groups. The incidence of adverse reactions in the TA\u00a0+\u00a0tripterygium glycosides group was lower in the control and TA groups. The final treatment effect of the experimental groups was better than the control group. The recurrence rate in the TA\u00a0+\u00a0tripterygium glycosides group was also significantly lower.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Tacrolimus and tripterygium glycosides combined therapy had better effects and safety for long\u2010term treatment of Henoch\u2013Sch\u00f6nlein purpura nephritis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.14665","type":"journal-article","created":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T00:55:20Z","timestamp":1628643320000},"page":"1157-1163","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Effect and safety evaluation of tacrolimus and tripterygium glycosides combined therapy in treatment of Henoch\u2013Sch\u00f6nlein purpura nephritis"],"prefix":"10.1111","volume":"28","author":[{"given":"Huiwu","family":"Zhang","sequence":"first","affiliation":[{"name":"Departments of Departments of Pediatrics Cangzhou Central Hospital Cangzhou Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuli","family":"Li","sequence":"additional","affiliation":[{"name":"Nephrology Cangzhou Central Hospital Cangzhou Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiping","family":"Xu","sequence":"additional","affiliation":[{"name":"Nephrology Cangzhou Central Hospital Cangzhou Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Ran","sequence":"additional","affiliation":[{"name":"Department of Nephrology Baoding First Central Hospital Cangzhou Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoxia","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neonatology Cangzhou Central Hospital Cangzhou Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12519-014-0534-5"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000511166"},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"265","DOI":"10.2174\/18756336MTA2lNDYc2","article-title":"Henoch\u2010Schonlein Purpura in children: an updated review","volume":"6","author":"Leung AKC","year":"2020","journal-title":"Curr. 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