{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T23:00:21Z","timestamp":1773356421852,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,9,3]],"date-time":"2021-09-03T00:00:00Z","timestamp":1630627200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To examine the effect of specific Asian ethnic subgroups on stage at presentation and cancer\u2010specific mortality in non\u2010metastatic upper tract urothelial carcinoma among North American upper tract urothelial carcinoma Asian patients treated with radical nephroureterectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We relied on the Surveillance, Epidemiology and End Results database, from 2004 to 2016. Kaplan\u2013Meier plots and multivariable Cox regression models predicting cancer\u2010specific mortality were used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 584 upper tract urothelial carcinoma patients, 173 (29.6%) were Chinese versus 130 (22.3%) Japanese versus 68 (11.6%) Korean versus 64 (11.0%) Filipino versus 40 (6.8%) Vietnamese versus 109 (18.7%) other. Vietnamese and Chinese patients showed the highest rates of T<jats:sub>4<\/jats:sub>N<jats:sub>0<\/jats:sub>M<jats:sub>0<\/jats:sub> and\/or T<jats:sub>1\u20134<\/jats:sub>N<jats:sub>1\u20132<\/jats:sub>M<jats:sub>0<\/jats:sub> (25.0% and 18.5%, respectively), relative to other Asian ethnic subgroups. In Kaplan\u2013Meier plots, Vietnamese patients showed the highest cancer\u2010specific mortality rate. In multivariable models, Vietnamese ethnicity also independently predicted higher cancer\u2010specific mortality (hazard ratio 2.15, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.02 and hazard ratio 1.96, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.03), relative to Japanese and Chinese patients. All other Asian ethnic subgroups showed similar cancer\u2010specific mortality patterns.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Vietnamese and Chinese patients are at a stage disadvantage at upper tract urothelial carcinoma diagnosis, relative to all other Asian ethnicities. After adjustment for stage, only Vietnamese patients showed a survival disadvantage relative to all other Asian ethnic subgroups. As a result, it appears that Vietnamese patients not only present at a higher upper tract urothelial carcinoma stage, but additionally appear to harbor upper tract urothelial carcinoma that progresses at a faster rate than in other Asian ethnic subgroups.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.14682","type":"journal-article","created":{"date-parts":[[2021,9,4]],"date-time":"2021-09-04T06:10:32Z","timestamp":1630735832000},"page":"1247-1252","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Stage and cancer\u2010specific mortality differ within specific Asian ethnic groups for upper tract urothelial carcinoma: North American population\u2010based study"],"prefix":"10.1111","volume":"28","author":[{"given":"Claudia","family":"Coll\u00e0 Ruvolo","sequence":"first","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit Division of Urology University of Montr\u00e9al Health Center Montr\u00e9al Quebec Canada"},{"name":"Department of Neurosciences, Reproductive Sciences and Odontostomatology Urology Unit University of Naples Federico II Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"W\u00fcrnschimmel","sequence":"additional","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit Division of Urology University of Montr\u00e9al Health Center Montr\u00e9al Quebec Canada"},{"name":"Martini\u2010Klinik Prostate Cancer Center University Hospital Hamburg\u2010Eppendorf Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Nocera","sequence":"additional","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit Division of Urology University of Montr\u00e9al Health Center Montr\u00e9al Quebec Canada"},{"name":"Department of Urology and Division of Experimental Oncology Urological Research Institute IBCAS San Raffaele Scientific Institute Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mike","family":"Wenzel","sequence":"additional","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit Division of Urology University of Montr\u00e9al Health Center Montr\u00e9al Quebec Canada"},{"name":"Department of Urology University Hospital Frankfurt Frankfurt am Main Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhe","family":"Tian","sequence":"additional","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit Division of Urology University of Montr\u00e9al Health Center Montr\u00e9al Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahrokh F","family":"Shariat","sequence":"additional","affiliation":[{"name":"Department of Urology Comprehensive Cancer Center Medical University of Vienna Vienna Austria"},{"name":"Department of Urology Weill Cornell Medical College New York City New York USA"},{"name":"Department of Urology University of Texas Southwestern Medical Center Dallas Texas USA"},{"name":"Department of Urology Second Faculty of Medicine Charles University Prague Czech Republic"},{"name":"Institute for Urology and Reproductive Health I.M. Sechenov First Moscow State Medical University Moscow Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fred","family":"Saad","sequence":"additional","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit Division of Urology University of Montr\u00e9al Health Center Montr\u00e9al Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Verze","sequence":"additional","affiliation":[{"name":"Urology Unit Department of Medicine and Surgery \u201cScuola Medica Salernitana\u201d University of Salerno Salerno Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ciro","family":"Imbimbo","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Reproductive Sciences and Odontostomatology Urology Unit University of Naples Federico II Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Briganti","sequence":"additional","affiliation":[{"name":"Department of Urology and Division of Experimental Oncology Urological Research Institute IBCAS San Raffaele Scientific Institute Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Mirone","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Reproductive Sciences and Odontostomatology Urology Unit University of Naples Federico II Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre I","family":"Karakiewicz","sequence":"additional","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit Division of Urology University of Montr\u00e9al Health Center Montr\u00e9al Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,9,3]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"U.S. Census Bureau. 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