{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T18:43:09Z","timestamp":1780598589583,"version":"3.54.1"},"reference-count":18,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T00:00:00Z","timestamp":1631664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To explore the influence of the microbiota of prostate secretion on the clinical status of patients with chronic bacterial prostatitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was an observational, single\u2010center, comparative study. We evaluated the survey cards of 230 outpatients aged 18\u201345\u00a0years with a history of prostatitis from 2012 to 2019. As a result, 170 outpatients were selected for the study. All patients underwent an assessment of symptoms using International Prostate Symptom Score\u2010quality of life, National Institutes of Health\u2010Chronic Prostatitis Symptom Index, International Index of Erectile Function, pain visual analog scale. A bacteriological study (after the Meares\u2013Stamey test) of post\u2010massage urine was carried out on an extended media set. The following parameters were determined in each patient: leukocyturia and bacteriuria, serum testosterone and total prostate\u2010specific antigen levels. Uroflowmetry, transrectal prostate ultrasound with color duplex mapping and ejaculate analysis were also carried out.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Aerobic\u2013anaerobic bacterial associations were identified in all patients. Three comparison groups were identified depending on the microbiota\u2019s spectrum (in post\u2010massage urine): aerobes prevailed in group\u00a01 (<jats:italic>n<\/jats:italic>\u00a0=\u00a067), anaerobes prevailed in group\u00a02 (<jats:italic>n<\/jats:italic>\u00a0=\u00a033), and the levels of aerobic and anaerobic bacteriuria were higher than \u226510<jats:sup>3<\/jats:sup>\u00a0colony\u2010forming units per mL in group\u00a03 (<jats:italic>n<\/jats:italic>\u00a0=\u00a070). It was found that the severity of clinical symptoms (urination disorders, sexual dysfunction etc.) of chronic bacterial prostatitis, laboratory and instrumental changes (testosterone, prostate\u2010specific antigen, prostate volume etc.) in groups\u00a02 and 3 were significantly higher than in group\u00a01.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In patients with chronic bacterial prostatitis, a predominance of anaerobes or a combination of aerobes and anaerobes in a titer of \u226510<jats:sup>3<\/jats:sup>\u00a0colony\u2010forming units per mL in post\u2010massage urine is associated with worse clinical status.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.14685","type":"journal-article","created":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T01:41:08Z","timestamp":1631756468000},"page":"1254-1259","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Does the microbiota spectrum of prostate secretion affect the clinical status of patients with chronic bacterial prostatitis?"],"prefix":"10.1111","volume":"28","author":[{"given":"Mikhail","family":"Kogan","sequence":"first","affiliation":[{"name":"Departments of Urology and Pediatric Urology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulia","family":"Naboka","sequence":"additional","affiliation":[{"name":"Microbiology and Virology No. 1 Rostov State Medical University Rostov\u2010on\u2010Don Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akhmed","family":"Ferzauli","sequence":"additional","affiliation":[{"name":"Departments of Urology and Pediatric Urology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalid","family":"Ibishev","sequence":"additional","affiliation":[{"name":"Departments of Urology and Pediatric Urology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Gudima","sequence":"additional","affiliation":[{"name":"Microbiology and Virology No. 1 Rostov State Medical University Rostov\u2010on\u2010Don Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1958-9858","authenticated-orcid":false,"given":"Ruslan","family":"Ismailov","sequence":"additional","affiliation":[{"name":"Departments of Urology and Pediatric Urology"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)63564-X"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)66541-X"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2007.08.028"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/RRU.S170400"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.4111\/icu.2017.58.6.460"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euf.2016.11.001"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics10060343"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01283-14"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medcli.2016.05.018"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/1404813"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12275-011-0391-z"},{"key":"e_1_2_7_13_1","first-page":"35","article-title":"Gram\u2010positive microorganisms isolated during chronic bacterial prostatitis investigation. A retrospective study","volume":"30","author":"Stamatiou K","year":"2019","journal-title":"Hell. 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