{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:46:07Z","timestamp":1761745567533,"version":"3.40.5"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T00:00:00Z","timestamp":1633305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004948","name":"Astellas Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004948","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To confirm if mirabegron 50\u2009mg shows efficacy in women with overactive bladder and either urgency urinary incontinence or mixed urinary incontinence versus placebo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Post\u2010hoc analyses were carried out using pooled data from a Japanese phase\u2009IIb and a phase\u2009III study. The primary efficacy end\u2010point was baseline to end\u2010of\u2010treatment change in the mean number of micturitions\/24\u2009h. The secondary end\u2010points were changes in the mean voided volume\/micturition, mean number of urgency and incontinence episodes\/24\u2009h, and mean number of nocturia episodes\/night. Other end\u2010points were quality of life and incontinence normalization rates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Women with urgency urinary incontinence (placebo <jats:italic>n<\/jats:italic>\u2009\u2009=\u2009204, mirabegron <jats:italic>n<\/jats:italic>\u2009=\u2009214) and mixed urinary incontinence (placebo <jats:italic>n<\/jats:italic>\u2009=\u2009122, mirabegron <jats:italic>n<\/jats:italic>\u2009=\u2009139) were included. Change in mean micturitions\/24\u2009h at end\u2010of\u2010treatment for mirabegron was statistically significant versus placebo in both populations; the effect size increased over time. For all secondary end\u2010points, median changes for mirabegron were statistically significant versus placebo at end\u2010of\u2010treatment, except for nocturia for the urgency urinary incontinence population and urgency for the mixed urinary incontinence population. Mirabegron showed larger improvements versus placebo in all quality\u2010of\u2010life domains, except for general health perception in the urgency urinary incontinence population. Incontinence normalization rates for mirabegron were 47.2% and 49.6% in the urgency urinary incontinence and mixed urinary incontinence populations, respectively, versus 42.6% and 39.3% for placebo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Mirabegron 50\u2009mg significantly improved key overactive bladder symptoms versus placebo in women with urgency urinary incontinence, and it also improved most overactive bladder symptoms, including micturition frequency, in patients with mixed urinary incontinence. These findings support the benefits of using mirabegron in the female overactive bladder wet population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.14700","type":"journal-article","created":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T02:59:20Z","timestamp":1633402760000},"page":"7-15","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Efficacy of mirabegron, a \u03b2<sub>3<\/sub>\u2010adrenoreceptor agonist, in Japanese women with overactive bladder and either urgency urinary incontinence or mixed urinary incontinence: Post\u2010hoc analysis of pooled data from two randomized, placebo\u2010controlled, double\u2010blind studies"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0819-9478","authenticated-orcid":false,"given":"Satoru","family":"Takahashi","sequence":"first","affiliation":[{"name":"Department of Urology Nihon University Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8176-0655","authenticated-orcid":false,"given":"Yuji","family":"Mishima","sequence":"additional","affiliation":[{"name":"Medical Affairs Astellas Pharma Inc. Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6682-2491","authenticated-orcid":false,"given":"Kentaro","family":"Kuroishi","sequence":"additional","affiliation":[{"name":"Data Science, Development Astellas Pharma Inc. Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7274-0126","authenticated-orcid":false,"given":"Masashi","family":"Ukai","sequence":"additional","affiliation":[{"name":"Medical Affairs Astellas Pharma Inc. 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