{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T16:43:43Z","timestamp":1758818623197,"version":"3.40.5"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T00:00:00Z","timestamp":1633305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the significant predictors of contralateral upper tract recurrence after radical nephroureterectomy for upper tract urothelial carcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between January 2001 and December 2015, 548 patients with upper tract urothelial carcinoma who underwent radical nephroureterectomy in a single institution were included in this retrospective cohort study. Several clinicopathological characteristics and outcomes were explored. The crucial end\u2010point was the diagnosis of contralateral upper tract recurrence after radical nephroureterectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 548 patients, the median age was 68\u2009years (range 24\u201393\u2009years), and the median follow\u2010up time after radical nephroureterectomy was 41\u2009months (range 8\u2013191\u2009months). Contralateral upper tract recurrence occurred in 28 patients (5.1%). The median time period between radical nephroureterectomy and contralateral upper tract recurrence was 15.4\u2009months (range 3.4\u201352.4\u2009months). In the multivariate analysis, preoperative estimated glomerular filtration rate &lt;30\u2009mL\/min\/1.73\u2009m<jats:sup>2<\/jats:sup> (hazard ratio 3.08, <jats:italic>P<\/jats:italic>\u2009=\u20090.003) and tumor multifocality (hazard ratio 2.16, <jats:italic>P<\/jats:italic>\u2009=\u20090.043) were independent risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Preoperative estimated glomerular filtration rate &lt;30 and tumor multifocality are significant predictors of contralateral upper tract recurrence after radical nephroureterectomy for upper tract urothelial carcinoma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.14718","type":"journal-article","created":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T00:44:45Z","timestamp":1633567485000},"page":"69-75","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Significant predictors of contralateral upper tract recurrence after radical nephroureterectomy for upper tract urothelial carcinoma"],"prefix":"10.1111","volume":"29","author":[{"given":"Chuan\u2010Shu","family":"Chen","sequence":"first","affiliation":[{"name":"Division of Urology Department of Surgery Taichung Veterans General Hospital Taichung Taiwan"},{"name":"Institute of Medicine Chung Shan Medical University Taichung Taiwan"},{"name":"Department of Senior Citizen Service Management National Taichung University of Science and Technology Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian\u2010Ri","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Urology Department of Surgery Taichung Veterans General Hospital Taichung Taiwan"},{"name":"Institute of Medicine Chung Shan Medical University Taichung Taiwan"},{"name":"Department of Medicine and Nursing Hungkuang University Taichung 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