{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T18:51:24Z","timestamp":1785783084622,"version":"3.56.0"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T00:00:00Z","timestamp":1633305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the efficacy, safety and tolerability of vibegron for the treatment of antimuscarinic\u2010resistant neurogenic bladder dysfunction in patients with spina bifida.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this retrospective study, 15 patients with antimuscarinic\u2010resistant neurogenic bladder dysfunction due to spina bifida underwent a video\u2010urodynamic study before and during the administration of vibegron 50\u2009mg once daily instead of antimuscarinic agents from February 2019 through April 2021. The video\u2010urodynamic study was carried out to evaluate bladder compliance, maximum cystometric bladder capacity, detrusor overactivity, detrusor leak point pressure and vesicoureteral reflux before and &gt;3\u2009months after the beginning of vibegron administration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Treatment with vibegron significantly improved bladder compliance and maximum cystometric bladder capacity compared with antimuscarinic agents, respectively (7.4\u2009\u00b1\u20094.2 <jats:italic>vs<\/jats:italic> 30.4\u2009\u00b1\u200948.2\u2009mL\/cmH<jats:sub>2<\/jats:sub>O, <jats:italic>P<\/jats:italic>\u2009=\u20090.0001; 231.4\u2009\u00b1\u200981.2 <jats:italic>vs<\/jats:italic> 325.2\u2009\u00b1\u2009106.5\u2009mL, <jats:italic>P<\/jats:italic>\u2009=\u20090.0005). Detrusor overactivity did not change after the administration of vibegron. Bladder deformity, which was confirmed in 12 patients, improved in half of the patients after taking vibegron. Vesicoureteral reflux, which was confirmed in two patients, was extinguished after taking vibegron. Newly occurring adverse events were not observed, and all patients continued to take vibegron during the treatment period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Favorable efficacy of vibegron for antimuscarinic\u2010resistant neurogenic bladder dysfunction due to spina bifida was shown video\u2010urodynamically without apparent adverse events. Vibegron is a favorable option for the treatment of antimuscarinic\u2010resistant neurogenic bladder dysfunction in patients with spina bifida.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.14720","type":"journal-article","created":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T00:41:59Z","timestamp":1633567319000},"page":"76-81","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Video\u2010urodynamic effects of vibegron, a new selective \u03b23\u2010adrenoceptor agonist, on antimuscarinic\u2010resistant neurogenic bladder dysfunction in patients with spina bifida"],"prefix":"10.1111","volume":"29","author":[{"given":"Katsuya","family":"Aoki","sequence":"first","affiliation":[{"name":"Department of Urology Nara Medical University Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Momose","sequence":"additional","affiliation":[{"name":"Department of Urology Hirao Hospital Kashihara Nara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Gotoh","sequence":"additional","affiliation":[{"name":"Department of Urology Nara Medical University Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosuke","family":"Morizawa","sequence":"additional","affiliation":[{"name":"Department of Urology Nara Medical University Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunta","family":"Hori","sequence":"additional","affiliation":[{"name":"Department of Urology Nara Medical University Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Nakai","sequence":"additional","affiliation":[{"name":"Department of Urology Nara Medical University Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makito","family":"Miyake","sequence":"additional","affiliation":[{"name":"Department of Urology Nara Medical University Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Anai","sequence":"additional","affiliation":[{"name":"Department of Urology Nara Medical University Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazumasa","family":"Torimoto","sequence":"additional","affiliation":[{"name":"Department of Urology Nara Medical University Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobumichi","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Urology Nara Medical University Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuo","family":"Yoneda","sequence":"additional","affiliation":[{"name":"Department of Urology Nara Medical University Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Urology Japan Community Health Care Organization Hoshigaoka Medical Center Hirakata Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyohide","family":"Fujimoto","sequence":"additional","affiliation":[{"name":"Department of Urology Nara Medical University Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,4]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.2165\/11592790-000000000-00000"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2013.10.046"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2017.01.037"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.12867"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2014.01.110"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000282252"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02388714"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410X.92.s1.2.x"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000000334"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2019-1544"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2005.12.056"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000106326"},{"key":"e_1_2_12_14_1","first-page":"840","article-title":"The prophylactic value of clean intermittent catheterization and anticholinergic medication in newborns and infants with myelodysplasia at risk of developing urinary tract deterioration","volume":"146","author":"Kasabian NG","year":"1992","journal-title":"Am. 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