{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T19:33:21Z","timestamp":1771788801223,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,10,27]],"date-time":"2021-10-27T00:00:00Z","timestamp":1635292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess temporal patterns and regional differences in the incidence rate, and factors associated with survival of urinary tract urothelial carcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The medical records of 8830 patients with new diagnoses of urinary tract urothelial carcinoma in the years 2001\u20132010 were retrieved from Taiwan National databases. Temporal trends, regional disparity and related survival factors were evaluated using the Cochran\u2013Armitage trend test, local Moran\u2019s <jats:italic>I<\/jats:italic> statistic and log\u2010rank test, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The annual urinary tract urothelial carcinoma incidence rates (standardized by age) were steady at approximately 3.14\u20133.41 per 100\u2009000 person\u2010years. Notably, women had a significantly higher annual urinary tract urothelial carcinoma incidence than men in most of the years studied (range of female\u2010to\u2010male annual standardized rate ratio: 2.08\u20133.25), and diabetes prevalence in urinary tract urothelial carcinoma increased significantly from 12.3% to 23.4% per year over the 10\u2009years. High urinary tract urothelial carcinoma incidence cluster areas other than the latest endemic area of \u201cblackfoot disease\u201d were newly identified by local Moran\u2019s <jats:italic>I<\/jats:italic> statistic (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Furthermore, older age, male sex, end\u2010stage kidney disease and more advanced tumor grade were associated with lower 5\u2010year overall survival probabilities in the 2001\u20132015 cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The incidence and survival of urinary tract urothelial carcinoma over the decade 2001\u20132010 were different according to population and regional features. Various urinary tract urothelial carcinoma screening, prevention, treatment and care plans should be developed depending on age, sex, comorbidity and area of residence.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.14731","type":"journal-article","created":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T00:03:19Z","timestamp":1635379399000},"page":"121-127","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Incidence and survival variations of upper tract urothelial cancer in Taiwan (2001\u20132010)"],"prefix":"10.1111","volume":"29","author":[{"given":"Ming\u2010Yen","family":"Lin","sequence":"first","affiliation":[{"name":"Division of Nephrology Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Kaohsiung Taiwan"},{"name":"Department of Renal Care College of Medicine Kaohsiung Medical University Kaohsiung 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Hospital I\u2010Shou University Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li\u2010Tzong","family":"Chen","sequence":"additional","affiliation":[{"name":"National Institute of Cancer Research National Health Research Institutes Tainan Taiwan"},{"name":"Division of Hematology and Oncology Department of Internal Medicine National Cheng Kung University Hospital Tainan Taiwan"},{"name":"Division of Gastroenterology Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen\u2010Jeng","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Urology Kaohsiung Medical University Hospital Kaohsiung Medical University Kaohsiung Taiwan"},{"name":"Department of Urology School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan"},{"name":"Department of Urology Ministry of Health and Welfare 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