{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T18:04:01Z","timestamp":1770401041286,"version":"3.49.0"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T00:00:00Z","timestamp":1636502400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate more comprehensively the presence of an association between childhood lower urinary tract symptoms and development of adulthood overactive bladder, to determine the group at most risk of overactive bladder in adulthood, and to assess its effects on daily life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 264 patients who were followed up for lower urinary tract symptoms in childhood between 2000 and 2005 were included in this retrospective, cohort study. After a median period of 20\u2009years, these patients with a median current age of 29 (27\u201335) years were re\u2010evaluated and divided into two groups: those currently with overactive bladder (<jats:italic>n<\/jats:italic> = 102, 23.0%), and those without overactive bladder (<jats:italic>n<\/jats:italic> = 162, 36.5%). In addition, 180 age\u2010matched overactive bladder patients without a history of childhood lower urinary tract symptoms (<jats:italic>n<\/jats:italic>\u2009=\u2009180, 40.5%) were included. The primary endpoint was to determine which children are at higher risk of adulthood overactive bladder. The secondary endpoint was to evaluate the effect of history of childhood lower urinary tract symptoms on quality of life in adulthood. The eight\u2010item Overactive Bladder questionnaire, the Pittsburgh Sleep Quality Index, and the Short\u2010Form 36\u2010item Health Survey were administered to all participants. Voiding Dysfunction Symptom Score was evaluated according to childhood medical records.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overactive bladder in adulthood was observed in 38.6% of patients recovering from childhood lower urinary tract symptoms. They had worse overactive bladder symptom scores and quality of life than those without childhood lower urinary tract symptoms (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Voiding Dysfunction Symptom Score \u226513 (odds ratio 2.54), daytime incontinence (odds ratio 2.01), holding maneuvers (odds ratio 1.82), nocturnal enuresis (odds ratio 1.75) in the pediatric period, and recovery age from all these symptoms of \u226512\u2009years (odds ratio 1.95) were the most unfavorable determinants of development of adulthood overactive bladder.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings show that children with the above characteristics are at risk of developing overactive bladder later in their lives even if their symptoms improve in childhood.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.14740","type":"journal-article","created":{"date-parts":[[2021,11,11]],"date-time":"2021-11-11T00:53:10Z","timestamp":1636591990000},"page":"136-142","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Which children are at risk of developing overactive bladder in early adulthood even if lower urinary tract symptoms improve during childhood?"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3578-0732","authenticated-orcid":false,"given":"Ismail","family":"Selvi","sequence":"first","affiliation":[{"name":"Department of Urology Ba\u015fak\u015fehir \u00c7am and Sakura City Hospital Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1770-5165","authenticated-orcid":false,"given":"Halil","family":"Basar","sequence":"additional","affiliation":[{"name":"Department of Urology Health Science University Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1017-3653","authenticated-orcid":false,"given":"Numan","family":"Baydilli","sequence":"additional","affiliation":[{"name":"Departments of Department of Urology and Erciyes University Medical School Kayseri Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1645-8409","authenticated-orcid":false,"given":"Emrah","family":"Kizilay","sequence":"additional","affiliation":[{"name":"Departments of Department of Urology and Erciyes University Medical School Kayseri Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9761-8488","authenticated-orcid":false,"given":"Deniz","family":"Demirci","sequence":"additional","affiliation":[{"name":"Department of Pediatric Urology Erciyes University Medical School Kayseri Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,11,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4160-6911-9.00066-9"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.5152\/tud.2016.93467"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2016.152"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.24275"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1677-5538.IBJU.2015.0579"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2013.12.051"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.12694"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)00416-7"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-020-03681-w"},{"key":"e_1_2_9_11_1","unstructured":"International Continence Society.ICS 2019 Standards.2019. 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