{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T22:38:41Z","timestamp":1787611121716,"version":"build-2736575974"},"reference-count":22,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T00:00:00Z","timestamp":1648512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>The impact of vesicoureteral reflux post\u2010kidney transplantation on graft survival remains unclear, and guidelines on appropriate vesicoureteral reflux management post\u2010kidney transplantation are lacking. For this reason, we conducted a retrospective study on the impact of vesicoureteral reflux and its treatment on graft survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We evaluated 347 consecutive kidney transplantation recipients, who also underwent a ureteroneocystostomy, between 1996 and 2012.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Vesicoureteral reflux was diagnosed in 55 cases (15.9%), with a median post\u2010kidney transplantation duration of 50\u2009months (range 0\u2013172\u2009months). Among these, 22 were monitored, 17 underwent transurethral collagen injections, and 16 received a ureteroneocystostomy. The 10\u2010year graft survival rate was significantly lower in recipients with vesicoureteral reflux (68.9%) than in those without vesicoureteral reflux (84.4%) (<jats:italic>P<\/jats:italic>\u2009=\u20090.0165). Moreover, among the vesicoureteral reflux recipients, the 10\u2010year graft survival rate was significantly higher in those whose vesicoureteral reflux was cured (80.1%) than in those whose vesicoureteral reflux persisted (53.6%) (<jats:italic>P<\/jats:italic>\u2009=\u20090.0062). Multivariate analysis showed that vesicoureteral reflux was significantly associated with both overall and death\u2010censored graft loss (odds ratio 3.737 and 3.685; <jats:italic>P<\/jats:italic>\u2009=\u20090.0015 and <jats:italic>P<\/jats:italic>\u2009=\u20090.0052, respectively). Lastly, the incidence of interstitial fibrosis and tubular atrophy was higher in recipients with vesicoureteral reflux than in those without vesicoureteral reflux (<jats:italic>P<\/jats:italic>\u2009=\u20090.0009).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Post\u2010kidney transplantation vesicoureteral reflux has a negative impact on long\u2010term graft survival, and that treatment prevents graft deterioration. From the perspective of maintaining long\u2010term graft function in kidney recipients, vesicoureteral reflux may be one of the most important complications to be addressed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.14876","type":"journal-article","created":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T00:54:25Z","timestamp":1648601665000},"page":"699-706","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Vesicoureteral reflux treatment following kidney transplantation potentially prevents graft function deterioration and allows long\u2010term graft survival"],"prefix":"10.1111","volume":"29","author":[{"given":"Takayuki","family":"Hirose","sequence":"first","affiliation":[{"name":"Department of Urology Hokkaido University Hospital  Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8080-5962","authenticated-orcid":false,"given":"Kiyohiko","family":"Hotta","sequence":"additional","affiliation":[{"name":"Department of Urology Hokkaido University Hospital  Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5121-6686","authenticated-orcid":false,"given":"Hiroshi","family":"Harada","sequence":"additional","affiliation":[{"name":"Department of Kidney Transplant Surgery Sapporo City General Hospital  Sapporo Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsu","family":"Tanabe","sequence":"additional","affiliation":[{"name":"Department of Urology Hokkaido University Hospital  Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajime","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Department of Urology Hokkaido University Hospital  Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuo","family":"Shinohara","sequence":"additional","affiliation":[{"name":"Department of Urology Hokkaido University Hospital  Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,29]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0012.2004.00245.x"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000226165.06196.84"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2008.04.009"},{"key":"e_1_2_13_5_1","first-page":"126","article-title":"Renal allograft with calcium oxalate deposition: association with urinary tract infection and development of interstitial fibrosis","volume":"16","author":"\u00d6zdemir BH","year":"2018","journal-title":"Exp. 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