{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T19:23:15Z","timestamp":1775416995385,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T00:00:00Z","timestamp":1658275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess real\u2010world oncological outcomes between the radical cystectomy (RC) group and non\u2010RC group for early relapse and refractory disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analyzed 953 patients with recurrent non\u2010muscle\u2010invasive bladder cancer (NMIBC) who received bacillus Calmette\u2010Gu\u00e9rin (BCG) at 31 affiliated hospitals from 2000 to 2019. Patients with missing data on the timing of failure were excluded and 871 patients remained eligible, of whom 447, 357, and 67 were classified as early relapse\/refractory disease, intermediate\/late relapse disease, and intolerant disease, respectively. For early relapse\/refractory disease, patients were divided into two salvage treatment groups: RC and non\u2010RC. The clinicopathological variables of each group were examined using Kaplan\u2013Meier plots and proportional Cox hazard ratios with matched score analyses to compare oncological outcomes between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significantly worse progression\u2010free survival and cancer\u2010specific survival (CSS) were confirmed in the early relapse\/refractory disease group compared to the intermediate\/late relapse group. Of the 88 salvage patients in the RC group with early relapse\/refractory disease, \u2264pT1 was observed in 47, pT2 in 11, and\u2009\u2265pT3 in 28 (two patients with unknown pT category). In early relapse\/refractory disease, the RC group showed significantly high\u2010risk tumor compared to the non\u2010RC group. However, no significant difference was observed in CSS after matched score analyses (<jats:italic>p<\/jats:italic>\u2009=\u20090.45) between the RC and non\u2010RC groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study found that the RC group showed no significant superiority compared to the non\u2010RC group in CSS for early relapse\/refractory disease in terms of first salvage therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.14976","type":"journal-article","created":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T00:54:06Z","timestamp":1658364846000},"page":"1195-1203","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Real\u2010world treatment patterns and oncological outcomes in early relapse and refractory disease after bacillus Calmette\u2010Gu\u00e9rin failure in non\u2010muscle\u2010invasive bladder cancer"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6071-218X","authenticated-orcid":false,"given":"Yasukiyo","family":"Murakami","sequence":"first","affiliation":[{"name":"Department of Urology Kitasato University School of Medicine  Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazumasa","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Urology Kitasato University School of Medicine  Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9503-7356","authenticated-orcid":false,"given":"Makito","family":"Miyake","sequence":"additional","affiliation":[{"name":"Department of Urology Nara Medical University  Kashihara Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriyuki","family":"Amano","sequence":"additional","affiliation":[{"name":"Department of Urology Kitasato University School of Medicine  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