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We performed a non\u2010systematic review of novel studies on focal therapy of localized prostate cancer as primary treatment published between 2016 and 2021. For mainly intermediate\u2010risk patients, therapeutic technology, such as cryoablation, brachytherapy, high\u2010intensity focused ultrasound, photodynamic therapy, microwave\u2010coagulation, electroporation, and laser ablation, etc., were performed. These procedures are minimally invasive and safe, and provide good functional outcome: a 94\u2013100% pad\u2010free rate against urinary incontinence and 47\u201386% erectile function, which is sufficient for sexual intercourse. Accurate three\u2010dimensional mapping of the targeted lesion could be an essential navigation technique for therapeutic success. Intermediate\u2010 to short\u2010term oncological outcomes were good, resulting in downstaging of the patient's status to no clinically significant cancer; however, transition to conventional whole\u2010gland treatment was necessary in about 10\u201330% of patients. It is important to select appropriate patients by both multiparametric magnetic resonance imaging and targeted biopsy, and to follow\u2010up postoperatively with methods such as active surveillance. Clinically significant prostate\u2010specific antigen reduction, image response using preoperative and postoperative multiparametric magnetic resonance imaging, and histological analysis should be combined for follow\u2010up.<\/jats:p>","DOI":"10.1111\/iju.14991","type":"journal-article","created":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T05:40:41Z","timestamp":1661233241000},"page":"1254-1263","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Focal therapy of localized prostate cancer"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5213-3831","authenticated-orcid":false,"given":"Atsuko","family":"Fujihara","sequence":"first","affiliation":[{"name":"Department of Urology Kyoto Prefectural University of Medicine  Kyoto 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