{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:17:30Z","timestamp":1747185450326,"version":"3.40.5"},"reference-count":27,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T00:00:00Z","timestamp":1660694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To identify the clinicopathological features of adrenal malignancies and analyze the prognoses of patients with adrenal cortical carcinoma (ACC) and malignant pheochromocytoma (MPCC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>We used a hospital\u2010based cancer registry data in Japan to extract cases of adrenal malignancies that were histologically confirmed, diagnosed, and initially treated from 2012\u20132015. For survival analysis, we used data from the 2008\u20132009 cohort to estimate 5\u2010year overall survival (OS) by the Kaplan\u2013Meier method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 989 adrenal malignancies were identified in the 2012\u20132015 cohort. The most common histologies were ACC (26.4%), diffuse large B\u2010cell lymphoma (DLBCL; 25.4%), neuroblastoma (22.2%), and MPCC (11.9%). While most ACC and MPCC patients were in their 60s, DLBCL patients accounted for 61.5% of adrenal malignancies in the over\u201070 cohort. Among ACC patients with clinical staging data, 46.3% of patients were stage IV. Although surgery was a chief strategy for all stages, younger patients tended to receive combination therapy, including surgery and chemotherapy or hormone therapy. In the 2008\u20132009 cohort, the 5\u2010year OS rates of ACC (<jats:italic>n<\/jats:italic>\u2009=\u200949) and MPCC (<jats:italic>n<\/jats:italic>\u2009=\u200923) patients were 56.2% and 86.4% while ACC patients without surgery had 1\u2010 and 2\u2010year OS rates of 25.0% and 12.5%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In Japan, DLBCL accounted for the majority of adrenal malignancies in older patients. Despite advanced staging, ACC patients were mainly treated with surgery and their prognosis was not satisfactory. Such epidemiological data may be useful in considering initial management strategies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.14996","type":"journal-article","created":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T15:31:55Z","timestamp":1660750315000},"page":"1331-1337","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinicopathological features of adrenal malignancies: Analysis of hospital\u2010based cancer registry data in Japan"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1463-144X","authenticated-orcid":false,"given":"Ichiro","family":"Chihara","sequence":"first","affiliation":[{"name":"Department of Urology University of Tsukuba  Tsukuba 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