{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T12:18:36Z","timestamp":1758629916360,"version":"3.40.5"},"reference-count":14,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T00:00:00Z","timestamp":1662508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2022,12]]},"abstract":"Abstract<\/jats:title>Objectives<\/jats:title>The study identified factors affecting anti\u2010S immunoglobulin G production after vaccination against severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) in kidney transplant recipients.<\/jats:p><\/jats:sec>Methods<\/jats:title>Serum samples were prospectively collected from kidney transplant recipients, live kidney donors, and healthy volunteers 1\u2009month after receiving the second dose of SARS\u2010CoV\u20102 vaccine, and anti\u2010S immunoglobulin G titers were measured. The mycophenolate mofetil dose was reduced before vaccination in some immunologically low\u2010risk recipients.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 151 kidney transplant recipients, 74 live kidney donors, and 50 healthy volunteers were included. Kidney transplant recipients had significantly lower titers of anti\u2010S immunoglobulin G than donors and healthy volunteers (1377\u2009\u00b1\u2009246, 8310\u2009\u00b1\u2009932, and 9908\u2009\u00b1\u20091040\u2009AU\/ml, respectively). Only 67.3% of kidney transplant recipients, compared to 100% of donors and healthy volunteers, were positive for anti\u2010S immunoglobulin G. Among the kidney transplant recipients, the anti\u2010S titer was higher in younger recipients, those with higher peripheral blood lymphocyte counts and glomerular filtration rates, those without a history of antithymocyte globulin use, and those who had discontinued or received a reduced dose of mycophenolate mofetil. Younger age, higher lymphocyte count, glomerular filtration rate, and mycophenolate reduction were significantly associated with anti\u2010S immunoglobulin G\u2009>\u20091000\u2009AU\/ml in nominal logistic regression analysis. There were no rejection episodes after mycophenolate modification in kidney transplant recipients.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Anti\u2010S immunoglobulin G production after vaccination was attenuated in kidney transplant recipients. Mycophenolate mofetil cessation or reduction is a modifiable means to enhance anti\u2010S immunoglobulin G production in immunosuppressed kidney transplant recipients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.15027","type":"journal-article","created":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T19:33:48Z","timestamp":1662579228000},"page":"1505-1510","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Temporary reduction of immunosuppression enhances production of anti\u2010S antibody against severe acute respiratory syndrome coronavirus 2 after vaccination in kidney transplant recipients"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8469-5326","authenticated-orcid":false,"given":"Masayoshi","family":"Miura","sequence":"first","affiliation":[{"name":"Department of Renal Transplant Surgery and Urology Sapporo Hokuyu Hospital Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2834-7271","authenticated-orcid":false,"given":"Maiko","family":"Fukumoto","sequence":"additional","affiliation":[{"name":"Transplant Supporting Office Sapporo Hokuyu Hospital Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7874-7185","authenticated-orcid":false,"given":"Natsumi","family":"Komatsu","sequence":"additional","affiliation":[{"name":"Transplant Supporting Office Sapporo Hokuyu Hospital Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9680-9012","authenticated-orcid":false,"given":"Reimi","family":"Shuto","sequence":"additional","affiliation":[{"name":"Transplant Supporting Office Sapporo Hokuyu Hospital Sapporo 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Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,9,7]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2019.06.014"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfaa261"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.02690221"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiph.2021.11.021"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.13705"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.13788"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.16713"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.16615"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.16818"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2019.03.061"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.16958"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.16851"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3062.2011.00665.x"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-04389-z"}],"container-title":["International 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