{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T08:15:37Z","timestamp":1782461737892,"version":"3.54.5"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T00:00:00Z","timestamp":1663113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We evaluated the relationship between penile curvature and testosterone in Peyronie's disease patients treated in Japan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were obtained from 109 patients with Peyronie's disease treated with surgery at our hospital between April 2004 and December 2019. Penile deformity assessment was based on findings of a rigid erection induced by intracavernosal injection. Low total testosterone level was defined as &lt;300\u2009ng\/dl. Patients were divided into two groups according to curvature severity (I, &lt;60\u00b0; II \u226560\u00b0), then clinical factors including total testosterone were compared. Uni\u2010 and multivariate logistic regression analyses were performed to identify factors predicting severe penile deformity (\u226560\u00b0).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For all patients, mean total testosterone was 469\u2009ng\/dl and median curvature was 50\u00b0, with a significant inverse correlation found between curvature and testosterone level (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). Group I and II patients numbered 55 and 54, respectively. Mean total testosterone for Group II was 397\u2009ng\/dl, significantly lower than Group I (539\u2009ng\/dl). Median curvature in 15 patients with a low testosterone level was 80\u00b0, significantly higher than those with a normal testosterone range (50\u00b0). Univariable and multivariable logistic regression analysis indicated total testosterone, follicle stimulating hormone, and C\u2010reactive protein as significant factors correlated with severe penile deformity, among which total testosterone was most relevant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The present findings confirmed that penile deformity severity is correlated with testosterone level in Japanese males with Peyronie's disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.15055","type":"journal-article","created":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T15:03:48Z","timestamp":1663167828000},"page":"36-42","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Significant inverse association of testosterone level with penile deformity severity in Japanese males with Peyronie's disease"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2919-0058","authenticated-orcid":false,"given":"Yozo","family":"Mitsui","sequence":"first","affiliation":[{"name":"Department of Urology Toho University Faculty of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumito","family":"Yamabe","sequence":"additional","affiliation":[{"name":"Department of Urology Toho University Faculty of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunsuke","family":"Hori","sequence":"additional","affiliation":[{"name":"Department of Urology Toho University Faculty of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Uetani","sequence":"additional","affiliation":[{"name":"Department of Urology Toho University Faculty of Medicine  Tokyo 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