{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:52:29Z","timestamp":1787014349195,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T00:00:00Z","timestamp":1666915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Radium\u2010223 (Ra\u2010223) dichloride is the bone\u2010targeted radioligand therapy that prolongs overall survival (OS) in patients with bone\u2010metastatic castration\u2010resistant prostate cancer (CRPC). We aimed to evaluate the safety and effectiveness of this treatment in real\u2010world practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We included Japanese men treated with Ra\u2010223 for bone\u2010metastatic CRPC from 10 institutions, retrospectively. Primary endpoint was OS. Secondary endpoint was maximum decline of alkaline phosphatase (ALP), lactate dehydrogenase, and prostate\u2010specific antigen values, the rate of adverse events, and time to pathological fracture after Ra\u2010223 treatment. Exploratory endpoint was the associations between clinical parameters and OS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 73 men with bone metastatic CRPC treated with Ra\u2010223 were enrolled. The median OS was 20.9\u2009months. ALP levels decreased significantly from pre\u2010treatment (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03). Anemia occurred in three (4.1%) patients. Grade\u2009\u2265\u20093 non\u2010pathological fractures occurred in four (5.5%) men. Nine (12.3%) patients presented pathological fracture; 7\/30 (23.3%) were in men without concomitant use of a bone\u2010modifying agent (BMA) while 2\/43 (4.7%) were in patients with concomitant BMA (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03). The median OS in patients with \u22653\u2009cycles treatment (27.2\u2009months,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) or hemoglobin \u226512\u2009g\/dl (27.2\u2009months,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) or absence of bone pain (36.3\u2009months,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004) was significantly longer compared to those who with \u22642\u2009cycles or hemoglobin&lt;12\u2009g\/dl or presence of bone paint, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study has shown the outcomes of Ra\u2010223 treatment in real\u2010world practice, where the number of treatment cycles, baseline anemia and bone pain may be useful to predict OS in Ra\u2010223 treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iju.15078","type":"journal-article","created":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T09:09:40Z","timestamp":1666948180000},"page":"139-146","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Effectiveness and safety of radium\u2010223 dichloride in patients with castration\u2010resistant prostate cancer and bone metastases in real\u2010world practice: A multi\u2010institutional study"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1570-6340","authenticated-orcid":false,"given":"Takashi","family":"Matsumoto","sequence":"first","affiliation":[{"name":"Department of Urology, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshifumi","family":"Hori","sequence":"additional","affiliation":[{"name":"Department of Urology Miyazaki Prefectural Miyazaki Hospital  Miyazaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3306-4858","authenticated-orcid":false,"given":"Masaki","family":"Shiota","sequence":"additional","affiliation":[{"name":"Department of Urology, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7383-5322","authenticated-orcid":false,"given":"Leandro","family":"Blas","sequence":"additional","affiliation":[{"name":"Department of Urology, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motonobu","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Urology National Hospital Organization Kyushu Cancer Center  Fukuoka 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