{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T09:47:30Z","timestamp":1769248050753,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T00:00:00Z","timestamp":1667174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000646","name":"Japan Society for the Promotion of Science London","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000646","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To describe oncological outcomes after progressive site\u2010directed therapy (PSDT) in genuine and induced oligometasatic (OM)\u2010castration\u2010resistant prostate cancer (CRPC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010seven patients with OM\u2010CRPC treated with PSDT were retrospectively analyzed, and oncological outcomes and recurrence patterns on whole\u2010body diffusion\u2010weighted MRI (WB\u2010DWI) were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010two (59%) were classified as genuine OM\u2010CRPC and 15 (41%) as induced OM\u2010CRPC. A 50% decline in PSA after PSDT was observed in 21 (95%) genuine OM\u2010CRPCs and 7 (47%) induced OM\u2010CRPCs (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.0005). At a median observation period of 7.3\u00a0months, median PSA progression\u2010free survival were 10.9\u00a0months in the genuine OM\u2010CRPCs and 4.8\u00a0months in the induced OM\u2010CRPCs (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.015). Among the patients who developed PSA progression after PSDT, 11 of 15 in the genuine OM\u2010CRPCs (73%) and 11 of 14 in the induced OM\u2010CRPCs (79%) underwent WB\u2010DWI at PSA progression. The median numbers of newly detected metastases were 2 (range: 1\u20135) in the genuine OM\u2010CRPCs and 4 (range: 1\u201340) in the induced OM\u2010CRPCs (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.049). Only one new metastasis appeared in 5 patients from the genuine OM\u2010CRPCs (46%) and 1 from the induced OM\u2010CRPCs (9.1%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.048). In 7 of 9 patients from the genuine OM\u2010CRPCs (78%) and 7 of 8 patients from the induced OM\u2010CRPCs (88%) who had bone metastases alone, the newly detected metastasis limited to the bone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Genuine OM\u2010CRPC had better oncological outcomes after PSDT than induced OM\u2010CRPC, and the number of lesions detected at recurrence was limited. Induced OM\u2010CRPC might be a disseminated condition with micrometastases at OM diagnosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.15090","type":"journal-article","created":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T09:02:17Z","timestamp":1667206937000},"page":"204-210","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Patterns of recurrence in genuine and induced oligometastatic castration\u2010resistant prostate cancer treated with progressive site\u2010directed therapy"],"prefix":"10.1111","volume":"30","author":[{"given":"Soichiro","family":"Yoshida","sequence":"first","affiliation":[{"name":"Department of Urology Tokyo Medical and Dental University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taro","family":"Takahara","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Tokai University School of Engineering  Kanagawa 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