{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T13:30:54Z","timestamp":1793107854022,"version":"4.5.0"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T00:00:00Z","timestamp":1687219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006120","name":"Ministry of the Environment","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006120","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Concerns exist regarding the effects of maternal inhalation of household products on fetal health. This study aimed to clarify the impact of maternal exposure to household products, including spray formulations, on urological anomalies in offspring up to the age of 1\u2009year.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study included data from 84\u2009237 children from the Japan Environment and Children's Study, an ongoing nationwide cohort study. Using maternal self\u2010report questionnaires, information on the use of organic solvents, waterproof sprays, insect\u2010repellent sprays, insecticide sprays, and herbicides from implantation until the second or third trimester of pregnancy and data on urological anomalies were collected 1\u2009year after delivery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Urological anomalies occurred in 799 infants. Multivariate logistic regression analysis adjusted for maternal age, pregnancy body mass index, gestational diabetes, pre\u2010existing maternal kidney disease, and preterm birth revealed no association between maternal exposure to organic solvents and the prevalence of offspring urological anomalies. Nevertheless, we observed significant associations between waterproof spray use during pregnancy and urological anomalies in boys (odds ratio [OR]: 1.28, 95% confidence interval [CI]: 1.03\u20131.59) and between the use of insecticide spray during pregnancy and urological anomalies in girls (OR: 1.48, 95% CI: 0.98\u20132.22). Sub\u2010analysis revealed significant associations between waterproof spray use during pregnancy and vesicoureteral reflux in boys (OR: 2.14, 95% CI: 1.02\u20134.49) and between the use of insecticide spray during pregnancy and hydronephrosis in girls (OR: 2.23, 95% CI: 1.11\u20134.47).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Spray formulation use during pregnancy might increase the risk of urological anomalies in the offspring.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.15229","type":"journal-article","created":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T11:44:29Z","timestamp":1687261469000},"page":"883-888","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association between maternal use of spray formulations and offspring urological anomalies: The Japan Environment and Children's Study"],"prefix":"10.1111","volume":"30","author":[{"given":"Yohei","family":"Taniguchi","sequence":"first","affiliation":[{"name":"Department of Pediatrics Hyogo Medical University School of Medicine  Nishinomiya Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0815-9193","authenticated-orcid":false,"given":"Hideki","family":"Shimomura","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hyogo Medical University School of Medicine  Nishinomiya Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Hasunuma","sequence":"additional","affiliation":[{"name":"Hyogo Regional Center for the Japan Environment and Children's Study  Nishinomiya Hyogo Japan"},{"name":"Department of Public Health Hyogo Medical University School of Medicine  Nishinomiya Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoko","family":"Taniguchi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hyogo Medical University School of Medicine  Nishinomiya Hyogo Japan"},{"name":"Hyogo Regional Center for the Japan Environment and Children's Study  Nishinomiya Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuro","family":"Fujino","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hyogo Medical University School of Medicine  Nishinomiya Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Utsunomiya","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hyogo Medical University School of Medicine  Nishinomiya Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masumi","family":"Okuda","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hyogo Medical University School of Medicine  Nishinomiya Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8783-7879","authenticated-orcid":false,"given":"Masayuki","family":"Shima","sequence":"additional","affiliation":[{"name":"Hyogo Regional Center for the Japan Environment and Children's Study  Nishinomiya Hyogo Japan"},{"name":"Department of Public Health Hyogo Medical University School of Medicine  Nishinomiya Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Takeshima","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hyogo Medical University School of Medicine  Nishinomiya Hyogo Japan"},{"name":"Hyogo Regional Center for the Japan Environment and Children's Study  Nishinomiya Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Japan Environment and Children's Study (JECS) Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,20]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/occmed\/kql115"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199804163381607"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.281.12.1106"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2015.05.008"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-1429"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.5619"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00038-012-0417-2"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.148.5.959"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1442-200X.2003.01779.x"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-4096.2001.woodward.2578.x"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03345105"},{"key":"e_1_2_14_13_1","first-page":"59","volume-title":"Reflux nephropathy","author":"Bailey R","year":"1979"},{"key":"e_1_2_14_14_1","first-page":"1062","article-title":"Ultrasound screening and follow\u2010up study of congenital anomalies of the kidney and urinary tract in neonates","volume":"51","author":"Li NN","year":"2019","journal-title":"Beijing Da Xue Xue Bao Yi Xue Ban"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.2188\/jea.JE20170018"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12199-017-0667-y"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-14-25"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12199-018-0733-0"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/oem.2008.041772"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)68992-6"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dez033"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.3109\/15563659509010620"},{"key":"e_1_2_14_23_1","first-page":"97","article-title":"Mosquito repellents, effectiveness in preventing diseases and safety during pregnancy","volume":"4","author":"Paumgartten FJR","year":"2016","journal-title":"Vigil Sanit Debate"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2014.11.017"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-016-3153-3"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-007-0479-1"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-016-3543-x"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-014-2884-6"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2010.05.066"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2010.05.065"}],"container-title":["International Journal of Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iju.15229","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T19:36:12Z","timestamp":1696534572000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iju.15229"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,20]]},"references-count":29,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1111\/iju.15229"],"URL":"https:\/\/doi.org\/10.1111\/iju.15229","archive":["Portico"],"relation":{},"ISSN":["0919-8172","1442-2042"],"issn-type":[{"value":"0919-8172","type":"print"},{"value":"1442-2042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,20]]},"assertion":[{"value":"2023-01-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}