{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T10:09:42Z","timestamp":1775383782684,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T00:00:00Z","timestamp":1689120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2023,11]]},"abstract":"Objective<\/jats:title>Our study aimed to compare surgical success rate (SR) and oral morbidity of augmentation urethroplasty for anterior urethral strictures using autologous tissue\u2010engineered oral mucosa graft (TEOMG) named MukoCell\u00ae versus native oral mucosa graft (NOMG).<\/jats:p><\/jats:sec>Methods<\/jats:title>We conducted a single\u2010institution observational study on patients undergoing TEOMG and NOMG urethroplasty for anterior urethral strictures >2\u2009cm in length from January 2016 to July 2020. SR, oral morbidity, and potential risk factors of recurrence were compared between groups were analyzed. A decrease of maximum uroflow rate\u2009<\u200915\u2009mL\/s or further instrumentation was considered a failure.<\/jats:p><\/jats:sec>Results<\/jats:title>Overall, TEOMG (n<\/jats:italic>\u2009=\u200977) and NOMG (n<\/jats:italic>\u2009=\u200976) groups had comparable SR (68.8% vs. 78.9%, p<\/jats:italic>\u2009=\u20090.155) after a median follow\u2010up of 52 (interquartile range [IQR] 45\u201360) months for TEOMG and 53.5 (IQR 43\u201358) months for NOMG. Subgroup analysis revealed comparable SR according to surgical technique, stricture localization, and length. Only following repetitive urethral dilatations, TEOMG achieved lower SR (31.3% vs. 81.3%, p<\/jats:italic>\u2009=\u20090.003). Surgical time was significantly shorter by TEOMG use (median 104 vs. 182\u2009min, p<\/jats:italic>\u2009<\u20090.001). Oral morbidity and the associated \u201cburden\u201d in patients' quality of life were significantly less at 3\u2009weeks following the biopsy required for TEOMG manufacture, compared to NOMG harvesting and totally absent at 6 and 12\u2009months postoperatively.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The SR of TEOMG urethroplasty appeared to be comparable to NOMG at a mid\u2010term follow\u2010up but taking into account the uneven distribution of stricture site and the surgical techniques used in both groups. Surgical time was significantly shortened, since no intraoperative mucosa harvesting was required, and oral complications were diminished through the preoperative biopsy for MukoCell\u00ae manufacture.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.15247","type":"journal-article","created":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T09:53:43Z","timestamp":1689155623000},"page":"1000-1007","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Comparison of oral morbidity and mid\u2010term efficacy of anterior urethroplasty using an autologous tissue\u2010engineered graft (MukoCell\u00ae) versus native oral mucosa graft"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7608-7673","authenticated-orcid":false,"given":"Leonidas","family":"Karapanos","sequence":"first","affiliation":[{"name":"Department of Urology, Uro\u2010Oncology, Robot\u2010Assisted and Reconstructive Surgery, Faculty of Medicine and University Hospital Cologne University of Cologne Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Knorr","sequence":"additional","affiliation":[{"name":"Department of Urology Staedtisches Klinikum Karlsruhe Karlsruhe Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luisa","family":"Halbe","sequence":"additional","affiliation":[{"name":"Department of Urology, Uro\u2010Oncology, Robot\u2010Assisted and Reconstructive Surgery, Faculty of Medicine and University Hospital Cologne University of Cologne Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maximilian","family":"Schmautz","sequence":"additional","affiliation":[{"name":"Department of Urology, Uro\u2010Oncology, Robot\u2010Assisted and Reconstructive Surgery, Faculty of Medicine and University Hospital Cologne University of Cologne Cologne 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