{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T05:16:17Z","timestamp":1770009377750,"version":"3.49.0"},"reference-count":19,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T00:00:00Z","timestamp":1690416000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Radium\u2010223 (Ra\u2010223) dichloride therapy increases overall survival and delays time to the first symptomatic skeletal event (SSE) in patients with castration\u2010resistant prostate cancer (CRPC) and bone metastases. Bone\u2010modifying agents (BMA) reduce SSE in patients with bone metastasis, but there is little information on their use with Ra\u2010223. This study aimed to investigate the effect of BMA on SSE in patients with bone metastatic CRPC treated with Ra\u2010223 in real\u2010world practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included 73 patients treated with Ra\u2010223 from 10 institutions in Japan. Time to the first SSE was estimated using the Kaplan\u2013Meier method and compared between groups using the log\u2010rank test. We used univariate analysis to ascertain the association between variables and SSE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During a median follow\u2010up of 12.7\u2009months (interquartile range, 7\u201321.7), 12 (16.4%) patients presented SSE. Age and BMA use were different between men with and without SSE. The 1\u2010year SSE\u2010free survival rate from Ra\u2010223 treatment initiation was 82.4% (95% CI, 69.4%\u201390.2%). BMA use was associated with favorable SSE\u2010free survival (hazard risk, 0.23; 95% confidence interval, 0.061\u20130.85; <jats:italic>p<\/jats:italic>\u2009=\u20090.027). Two (4.7%) and seven (23.3%) patients presented symptomatic pathological bone fracture in groups with and without BMA use, respectively (<jats:italic>p<\/jats:italic>\u2009=\u20090.017).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study stresses the importance of BMA use in patients with CRPC and bone metastases in Ra\u2010223 treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.15259","type":"journal-article","created":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T04:39:06Z","timestamp":1690519146000},"page":"1029-1034","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Bone\u2010modifying agents are protective for symptomatic skeletal events in Radium\u2010223 treatment"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7383-5322","authenticated-orcid":false,"given":"Leandro","family":"Blas","sequence":"first","affiliation":[{"name":"Department of Urology, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3306-4858","authenticated-orcid":false,"given":"Masaki","family":"Shiota","sequence":"additional","affiliation":[{"name":"Department of Urology, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Urology, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshifumi","family":"Hori","sequence":"additional","affiliation":[{"name":"Department of Urology Miyazaki Prefectural Miyazaki Hospital  Miyazaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motonobu","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Urology National Hospital Organization Kyushu Cancer Center  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narihito","family":"Seki","sequence":"additional","affiliation":[{"name":"Department of Urology Kyushu Central Hospital  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kentaro","family":"Kuroiwa","sequence":"additional","affiliation":[{"name":"Department of Urology Miyazaki Prefectural Miyazaki Hospital  Miyazaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Yokomizo","sequence":"additional","affiliation":[{"name":"Department of Urology Harasanshin Hospital  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Futoshi","family":"Morokuma","sequence":"additional","affiliation":[{"name":"Department of Urology Saga\u2010ken Medical Centre Koseikan  Saga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keijiro","family":"Kiyoshima","sequence":"additional","affiliation":[{"name":"Department of Urology Japanese Red Cross Fukuoka Hospital  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatoshi","family":"Eto","sequence":"additional","affiliation":[{"name":"Department of Urology, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,7,27]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2020.09.046"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.12.4008"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.01.529"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2014.70"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra030831"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djh141"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)62344-6"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1213755"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)70474-7"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdw065"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.15008"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.3459"},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-020-01776-w"},{"key":"e_1_2_15_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2021.11.005"},{"key":"e_1_2_15_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.15078"},{"key":"e_1_2_15_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.32851"},{"key":"e_1_2_15_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30860-X"},{"key":"e_1_2_15_20_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2021.39.15_suppl.5002"}],"container-title":["International Journal of Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iju.15259","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T16:28:03Z","timestamp":1698856083000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iju.15259"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,27]]},"references-count":19,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["10.1111\/iju.15259"],"URL":"https:\/\/doi.org\/10.1111\/iju.15259","archive":["Portico"],"relation":{},"ISSN":["0919-8172","1442-2042"],"issn-type":[{"value":"0919-8172","type":"print"},{"value":"1442-2042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,27]]},"assertion":[{"value":"2023-05-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}