{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T21:27:57Z","timestamp":1760218077830,"version":"3.40.5"},"reference-count":21,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T00:00:00Z","timestamp":1692662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Bladder cancer, especially non\u2010muscle invasive bladder cancer (NMIBC), is one of the most costly cancers owing to its long\u2010term management. Photodynamic diagnosis\u2010assisted transurethral resection of bladder tumor (PDD\u2010TURBT) reduces the risk of intravesical recurrence. However, its impact on healthcare economics in Japan remains unclear. We evaluated the comprehensive medical costs of Japanese healthcare economics regarding PDD\u2010TURBT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This large\u2010scale, multicenter, retrospective study included a dataset of 1531 patients who were diagnosed with primary NMIBC who underwent initial TURBT between April 2006 and June 2021. A one\u2010to\u2010one propensity\u2010score matching analysis was used for an unbiased comparison based on postTURBT follow\u2010up periods. The total medical costs, including hospitalization, surgical procedures for TURBT and salvage radical cystectomy, adjuvant intravesical therapies, and follow\u2010up examinations, were compared between white light (WL)\u2010TURBT and PDD\u2010TURBT groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After propensity\u2010score matching, 468 patients each of WL\u2010 and PDD\u2010TURBT groups were matched. Total costs were 510\u2009337\u2009128 and 514\u2009659\u2009328 \u00a5 in WL\u2010 and PDD\u2010TURBT groups, respectively. The costs of adjuvant intravesical therapies, follow\u2010up examinations, and salvage radical cystectomy in PDD\u2010TURBT group were equivalent to or lower than those in WL\u2010TURBT group. Furthermore, total costs of high\u2010 and highest\u2010risk NMIBC in PDD\u2010TURBT group were either equivalent or lower compared to those in WL\u2010TURBT group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The total costs associated with PDD\u2010TURBT were higher compared to WL\u2010TURBT, while there is the potential of PDD\u2010TURBT to reduce the burden on healthcare economics in limited cases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.15283","type":"journal-article","created":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T09:20:03Z","timestamp":1692696003000},"page":"1112-1119","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Impact on Japanese healthcare economics of photodynamic diagnosis\u2010assisted transurethral resection of bladder tumor for non\u2010muscle invasive bladder cancer: A multicenter retrospective cohort study"],"prefix":"10.1111","volume":"30","author":[{"given":"Nobutaka","family":"Nishimura","sequence":"first","affiliation":[{"name":"Department of Urology Nara Medical University  Kashihara Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9503-7356","authenticated-orcid":false,"given":"Makito","family":"Miyake","sequence":"additional","affiliation":[{"name":"Department of Urology Nara Medical University  Kashihara Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomonori","family":"Nakahama","sequence":"additional","affiliation":[{"name":"Department of Urology Nara Medical University  Kashihara Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0065-881X","authenticated-orcid":false,"given":"Tatsuki","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Department of Urology Nara Medical University  Kashihara Nara 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