{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T03:09:12Z","timestamp":1788577752168,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T00:00:00Z","timestamp":1693785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Clinical guidelines recommend that patients with non\u2010muscle\u2010invasive bladder cancer (NMIBC) should be treated with appropriate adjuvant therapy. However, compliance with guideline recommendations is insufficient, and this may lead to unfavorable outcomes. We aimed to investigate the level of adherence to guideline recommendations in patients with NMIBC and evaluate the outcomes of those who did and did not receive guideline\u2010recommended therapies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective analysis of patients with histologically diagnosed NMIBC. The percentage of patients with intermediate\u2010 and high\u2010risk tumors who received adjuvant intravesical therapy or second transurethral resection (TUR) was calculated. Recurrence\u2010free survival was assessed in patients who did and did not receive the therapies. We conducted a propensity score\u2010matched analysis to compare outcomes between patients with intermediate\u2010risk and T1 NMIBC who did and did not undergo guideline\u2010recommended therapies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 1204 patients from the Tohoku Urological Evidence\u2010Based Medicine Study Group and Kyoto University Hospital were included. Of patients with intermediate\u2010 and high\u2010risk tumors, 91.0% and 74.0% did not receive maintenance bacillus Calmette\u2013Gu\u00e9rin (BCG), respectively. In both groups, significantly better recurrence\u2010free survival was found for patients treated with maintenance BCG. Among patients with T1 NMIBC, only 16.7% underwent guideline\u2010recommended therapies, that is, a second TUR and maintenance BCG. Significantly greater recurrence\u2010free survival was observed in patients who received guideline\u2010recommended therapies compared with propensity\u2010matched patients who did not.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Guideline\u2010recommended therapies may contribute to improvements in outcomes for patients with NMIBC, suggesting that improvements in adherence to clinical guidelines may lead to favorable outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.15294","type":"journal-article","created":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T12:09:21Z","timestamp":1693829361000},"page":"1155-1163","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Improving compliance with guidelines may lead to favorable clinical outcomes for patients with non\u2010muscle\u2010invasive bladder cancer: A\u00a0retrospective multicenter 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