{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T04:21:23Z","timestamp":1788409283337,"version":"build-2803163510"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T00:00:00Z","timestamp":1696550400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Multiple clinical practice guidelines, conflicting evidence, and physician perceptions result in variations in risk stratification among patients with non\u2010muscle\u2010invasive bladder cancer (NMIBC). This study aims to describe the extent of this variation and its impact on management approaches in the Asia\u2010Pacific region.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a cross\u2010sectional survey involving 32 urologists and seven medical oncologists with \u22658\u2009years of experience managing early\u2010stage bladder cancer patients across Australia, Hong Kong, Japan, South Korea, Singapore, and Taiwan. The physicians completed an anonymous questionnaire that assessed their risk stratification and respective management approaches, based on 19 NMIBC characteristics. For each NMIBC characteristic, they were required to select one risk group, and their most preferred management approach.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our results demonstrated a higher consensus on risk classification versus management approaches. More than 50% of the respondents agreed on the risk classification of all NMIBC characteristics, but 42% or fewer chose the same treatment option as their preferred choice for all but two characteristics\u2014existence of variant histology (55%) and persistent high\u2010grade T1 disease on repeat resection (52%). Across territories, there was the greatest variation in preferred treatment options (i.e., no treatment, intravesical chemotherapy, or Bacillus Calmette\u2010Gu\u00e9rin [BCG] treatment) for intermediate\u2010risk patients and the highest consensus on the treatment of very high\u2010risk patients, namely radical cystectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study revealed considerable variation in risk stratification and management of NMIBC in the region. It is critical to develop practical algorithms to facilitate the recognition of NMIBC and standardize the treatment of NMIBC patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.15309","type":"journal-article","created":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T15:19:43Z","timestamp":1696605583000},"page":"64-71","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Risk stratification and management of non\u2010muscle\u2010invasive bladder cancer: A physician survey in six <scp>Asia\u2010Pacific<\/scp> territories"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5874-9167","authenticated-orcid":false,"given":"Ja Hyeon","family":"Ku","sequence":"first","affiliation":[{"name":"Seoul National University  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8208-0635","authenticated-orcid":false,"given":"Lui Shiong","family":"Lee","sequence":"additional","affiliation":[{"name":"Seng Kang General Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzu\u2010Ping","family":"Lin","sequence":"additional","affiliation":[{"name":"Taipei Veterans General Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1624-6676","authenticated-orcid":false,"given":"Eiji","family":"Kikuchi","sequence":"additional","affiliation":[{"name":"St Marianna University School of Medicine  Kawasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Kitamura","sequence":"additional","affiliation":[{"name":"University of Toyama  Toyama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1723-9646","authenticated-orcid":false,"given":"Chi\u2010Fai","family":"Ng","sequence":"additional","affiliation":[{"name":"The Chinese University of Hong Kong  Hong Kong Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junice Yi Siu","family":"Ng","sequence":"additional","affiliation":[{"name":"IQVIA Asia\u2010Pacific  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren Ming\u2010Chun","family":"Poon","sequence":"additional","affiliation":[{"name":"Hong Kong Sanatorium &amp; 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