{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:52:22Z","timestamp":1787014342263,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T00:00:00Z","timestamp":1696550400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate who needs a careful postoperative monitoring for prostate cancer (PCa) after holmium laser enucleation of the prostate (HoLEP). We examined characteristics and oncological outcomes of HoLEP\u2010related PCa.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients who underwent HoLEP during 2002\u20132017 in a Japanese tertiary center were retrospectively analyzed. Patients were divided into non\u2010PCa, PCa with HoLEP specimen (PCa\u2010Ope), and PCa diagnosed during follow\u2010up (PCa\u2010Post). Outcomes of all HoLEP\u2010related PCa were monitored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the total 758, 60 (7.9%) were diagnosed with PCa from resected specimen of HoLEP and 9 (1.2%) were diagnosed postoperatively. Preoperative prostate\u2010specific antigen (iPSA), postoperative PSA (pPSA), and PSA density were significantly higher in both PCa groups than those in non\u2010PCa group. While iPSA significantly correlated to prostate volume (PV), pPSA was not associated with PV. A receiver\u2010operating\u2010characteristics curve demonstrated that pPSA 1.2\u2009ng\/mL achieved the optimal cut\u2010off (AUC 0.95) for the incidence of PCa\u2010Post. In addition to the incidence of PCa and iPSA, lower enucleation efficiency (enucleated volume \/PV) was significantly associated with pPSA &gt;1.2\u2009ng\/mL. Among PCa\u2010Ope, 51 were Grade Group (GG) \u22642 and 42 were followed\u2010up with active surveillance, whereas 8 of 9 PCa\u2010Post were GG \u22653 and 2 progressed to death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients undergoing HoLEP are associated with some risk of potential PCa. While oncological outcomes were favorable among PCa\u2010Ope, postoperative PSA should be carefully monitored even if not diagnosed with PCa with HoLEP specimen. Enucleation efficiency should be also considered not to misread pPSA value.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iju.15315","type":"journal-article","created":{"date-parts":[[2023,10,8]],"date-time":"2023-10-08T14:29:56Z","timestamp":1696775396000},"page":"82-87","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Prostate\u2010specific antigen follow\u2010up and management for patients undergoing holmium laser enucleation of the prostate"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2164-3091","authenticated-orcid":false,"given":"Shingo","family":"Kimura","sequence":"first","affiliation":[{"name":"Department of Urology Sendai City Hospital  Sendai Japan"},{"name":"Department of Urology Tohoku University Graduate School of Medicine  Sendai 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