{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T12:54:06Z","timestamp":1770900846996,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T00:00:00Z","timestamp":1697414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>This study investigated disease\u2010free survival and oncological outcomes in penile cancer patients treated surgically at a high\u2010volume center and identified the prognostic factors for disease\u2010free survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis was conducted on primary penile cancer patients diagnosed and treated at Songklanagarind Hospital, Thailand, between January 2001 and December 2021. Disease\u2010free survival (DFS) was assessed using Kaplan\u2013Meier survival curves, and Cox proportional hazard models were used for multivariate analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 188 patients with primary penile cancer. The majority (98.4%) were uncircumcised. Tumor staging revealed 40.6% with T1 tumors, 72.9% with well\u2010differentiated tumors, and 23.5% diagnosed at stage IIIA. The recurrence rate was 19.1%, with a mean time to recurrence of 25.9\u2009months. Disease\u2010free survival rates at 1, 3, and 5\u2009years were 81.1%, 70.9%, and 70.9%, respectively. Median overall survival was 16.43\u2009months, with survival rates at 1, 3, and 5\u2009years at 67.7%, 42.7%, and 35.4%, respectively. Cox proportional hazard models showed significant associations between disease\u2010free survival and a higher T stage, a high level of CRP (&gt;15\u2009mg\/L), delayed onset of symptoms, primary lesion location, groin node metastasis, lymphovascular invasion, and pelvic lymph node metastases. However, multivariate analysis revealed that a higher primary tumor stage (T) was the only independent prognostic factor for disease\u2010free survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study presents one of the largest cohorts investigating disease\u2010free survival outcomes in penile cancer treatment at a single institution over a prolonged period. A higher pathologic T stage is a significant prognostic factor for disease\u2010free survival. Further large\u2010scale prospective studies are needed for validation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.15326","type":"journal-article","created":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T05:30:17Z","timestamp":1697520617000},"page":"144-153","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Real world data of recurrent and survival rates of penile cancer patients in Songklanagarind hospital: Tumor stage as a predictor for <scp>disease\u2010free<\/scp> survival"],"prefix":"10.1111","volume":"31","author":[{"given":"Natthakan","family":"Pinkheaw","sequence":"first","affiliation":[{"name":"Division of Urology, Department of Surgery, Faculty of Medicine Prince of Songkla University  Hat Yai Songkhla Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chirawadee","family":"Sathitruangsak","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand Prince of Songkla University  Songkhla Hat Yai Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monthira","family":"Tanthanuch","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery, Faculty of Medicine Prince of Songkla University  Hat Yai Songkhla Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0853-2653","authenticated-orcid":false,"given":"Tanan","family":"Bejrananda","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery, Faculty of Medicine Prince of Songkla University  Hat Yai Songkhla Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,10,16]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.21037\/tau.2017.05.19"},{"key":"e_1_2_11_3_1","unstructured":"The Global Cancer Observatory\u2014All Rights Reserved\u2014March 2021. 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