{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T09:30:04Z","timestamp":1782552604756,"version":"3.54.5"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T00:00:00Z","timestamp":1697760000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Recently, a close association between ulcerative colitis (UC) and erectile dysfunction (ED) was reported. An inverse relationship between serum albumin and ED is found in patients with chronic disease. However, the association between serum albumin levels and ED in patients with UC is unclear. This study aims to investigate this issue in Japanese patients with UC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred and thirty\u2010six Japanese male UC patients were enrolled in this study. Information on serum albumin levels and medications for UC from medical records, Sexual Health Inventory for Men (SHIM) score information from self\u2010administered questionnaires and information on the severity of UC from physician reports were obtained from medical records, self\u2010administered questionnaires, and reports from physicians. The participants were divided into tertiles based on the total protein, serum globulin, serum albumin, aspartate aminotransferase, and C\u2010reactive protein levels. The definition of ED and severe ED was SHIM score\u2009&lt;\u200922 and SHIM score\u2009&lt;\u20098, respectively. The association between these serum markers and ED was assessed by multivariate logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of severe ED in the low, moderate, and high albumin groups was 66.0%, 51.0%, and 28.3%, respectively. After adjusting for confounding factors, the low albumin group was independently and positively associated with severe ED (adjusted odds ratio: 2.74, 95% confidence interval: 1.03\u20137.48, <jats:italic>p<\/jats:italic> for trend =0.044). No association between other marker and ED was found.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Serum albumin was independently inversely associated with severe ED in Japanese patients with UC. Hypoalbuminemia might be a useful complementary marker for assessing the prevalence and severity of ED in UC patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.15327","type":"journal-article","created":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T12:14:43Z","timestamp":1697804083000},"page":"154-159","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Serum albumin levels as a useful complementary marker for erectile dysfunction in ulcerative colitis: A cross\u2010sectional study"],"prefix":"10.1111","volume":"31","author":[{"given":"Yasunori","family":"Yamamoto","sequence":"first","affiliation":[{"name":"Endoscopy Center Ehime University Hospital  Toon Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0041-7688","authenticated-orcid":false,"given":"Shinya","family":"Furukawa","sequence":"additional","affiliation":[{"name":"Health Services Center Ehime 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