{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:18:26Z","timestamp":1747185506041,"version":"3.40.5"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,1,5]],"date-time":"2024-01-05T00:00:00Z","timestamp":1704412800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871149"],"award-info":[{"award-number":["81871149"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>To analyze the characteristics of early clinical symptoms of hemorrhagic cystitis (HC) after hematopoietic stem cell transplantation (HSCT) and the risk factors of severe HC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analyzed 77 children with post\u2010HSCT HC treated at our hospital between June 2013 and June 2021. Clinical characteristics were collected and catalogued.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the children with urinary tract irritation symptoms (UTIS) as the first symptom, symptoms appeared earlier than hematuria symptoms (28\u2009day vs. 31\u2009day, <jats:italic>p<\/jats:italic>\u2009=\u20090.027), and the time progressing to severe HC was significantly longer in these children (12\u2009day vs. 7\u2009day, <jats:italic>p<\/jats:italic>\u2009=\u20090.038), but there was no significant difference in the number of participants (57.8% vs. 59.4%, <jats:italic>p<\/jats:italic>\u2009=\u20090.889). BK polyomavirus (BKV) infection was an independent risk factor (hazard ratio [HR]\u2009=\u20092.782, <jats:italic>p<\/jats:italic>\u2009=\u20090.035) for severe HC, which was also positively associated with multi\u2010viral infection (HR\u2009=\u20092.215, <jats:italic>p<\/jats:italic>\u2009=\u20090.020).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In HC children, when the first urinary tract symptom was UTIS, it appeared earlier than hematuria, and the time of progression to severe HC was significantly longer, suggesting that we still need more aggressive treatment for these children to prevent the worsening of symptoms. The severity of HC was positively correlated with BKV infection and multiple infections.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.15365","type":"journal-article","created":{"date-parts":[[2024,1,5]],"date-time":"2024-01-05T11:19:30Z","timestamp":1704453570000},"page":"335-341","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Analysis of early clinical signs and risk factors for severe hemorrhagic cystitis after stem cell transplantation in children"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2193-2926","authenticated-orcid":false,"given":"Pengtao","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Urology, Shanghai Children's Medical Center Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7815-987X","authenticated-orcid":false,"given":"Kaiping","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Urology, Shanghai Children's Medical Center Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Urology, Shanghai Children's Medical Center Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Urology, Shanghai Children's Medical Center Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,1,5]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2021.10056"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2009.02.199"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2005.06.007"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/941820"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-022-06916-8"},{"key":"e_1_2_15_7_1","first-page":"12","article-title":"ECIL guidelines for the prevention, diagnosis and treatment of BK polyomavirus\u2010associated haemorrhagic cystitis in haematopoietic stem cell transplant recipients","volume":"73","author":"Cesaro S","year":"2018","journal-title":"J Antimicrob Chemother"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2006.02.042"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.0253\u20102727.2021.04.002"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-4295(82)90633-1"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-015-0443-5"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705139"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198607243150405"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.5489\/cuaj.5993"},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2013.08.007"},{"key":"e_1_2_15_16_1","doi-asserted-by":"publisher","DOI":"10.23876\/j.krcp.18.0063"},{"key":"e_1_2_15_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14030764"},{"key":"e_1_2_15_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-021-04454-7"},{"key":"e_1_2_15_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1083-8791(03)00269-6"},{"key":"e_1_2_15_20_1","doi-asserted-by":"publisher","DOI":"10.4103\/jgid.jgid_139_21"}],"container-title":["International Journal of Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iju.15365","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,10]],"date-time":"2024-11-10T10:53:15Z","timestamp":1731235995000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iju.15365"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,5]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1111\/iju.15365"],"URL":"https:\/\/doi.org\/10.1111\/iju.15365","archive":["Portico"],"relation":{},"ISSN":["0919-8172","1442-2042"],"issn-type":[{"type":"print","value":"0919-8172"},{"type":"electronic","value":"1442-2042"}],"subject":[],"published":{"date-parts":[[2024,1,5]]},"assertion":[{"value":"2023-02-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}