{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:52:28Z","timestamp":1787014348844,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T00:00:00Z","timestamp":1704153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC112\u20102314\u2010B\u2010182A\u2010057"],"award-info":[{"award-number":["NSTC112\u20102314\u2010B\u2010182A\u2010057"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["MOST 110\u20102314\u2010B\u2010182A\u2010050\u2010MY3"],"award-info":[{"award-number":["MOST 110\u20102314\u2010B\u2010182A\u2010050\u2010MY3"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To investigate the prognostic impact of variant histology (VH) on oncological outcomes in patients with upper urinary tract urothelial carcinoma (UTUC) who had undergone radical nephroureterectomy (RNU).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>A total of 1239 patients with clinically localized UTUC who underwent RNU at a single institution between January 2005 and June 2020 were included. The VH was reviewed by a uro\u2010pathologist at our institution. The Cox regression model was used to perform multivariate analysis, including VH and other established prognostic factors for post\u2010RNU oncological outcomes (intravesical recurrence [IVR], non\u2010urothelial recurrence, and cancer\u2010specific death).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 1239 patients with UTUC, 384 patients (31%) were found to have VH. Advanced tumor stage, lymph node metastasis, high tumor grade, lymphovascular invasion, open surgery, and renal pelvis had a significantly larger proportion of UTUC with VH compared to pure UTUC (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). VH was an independent prognostic factor associated with less IVR identified by multivariate analysis, more non\u2010urothelial recurrence, and more cancer\u2010specific mortality.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patients with VH account for 31% with UTUC treated with RNU in this cohort. VH was an independent prognostic factor associated with more non\u2010urothelial recurrence and cancer\u2010specific mortality but less IVR.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iju.15376","type":"journal-article","created":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T02:44:25Z","timestamp":1704249865000},"page":"410-418","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Variant histology is associated with more non\u2010urothelial tract recurrence but less intravesical recurrence for upper tract urothelial carcinoma after radical nephroureterectomy"],"prefix":"10.1111","volume":"31","author":[{"given":"Tsung Yu","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Urology Kaohsiung Chang Gung Memorial Hospital and Chang Gung University and College of Medicine  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hung Jen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Urology Kaohsiung Chang Gung Memorial Hospital and Chang Gung University and College of Medicine  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Tse","family":"Sung","sequence":"additional","affiliation":[{"name":"Department of Pathology Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao Chi","family":"Chuang","sequence":"additional","affiliation":[{"name":"Department of Urology Kaohsiung Chang Gung Memorial Hospital and Chang Gung University and College of Medicine  Kaohsiung Taiwan"},{"name":"Center for Shockwave Medicine and Tissue Engineering Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen Ta","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Urology Kaohsiung Chang Gung Memorial Hospital and Chang Gung University and College of Medicine  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan Tso","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Urology Kaohsiung Chang Gung Memorial Hospital and Chang Gung University and College of Medicine  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih Hsiung","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Urology Kaohsiung Chang Gung Memorial Hospital and Chang Gung University and College of Medicine  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui Ying","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Urology Kaohsiung Chang Gung Memorial Hospital and Chang Gung University and College of Medicine  Kaohsiung 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